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PMID: 22344221 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.

Nature genetics ·Vol. 44 ·No. 3 ·2012-02-19 ·Pages 302-6

Okada Y, Kubo M, Ohmiya H, Takahashi A, Kumasaka N, Hosono N, Maeda S, Wen W, Dorajoo R, Go MJ, Zheng W, Kato N, Wu JY, Lu Q, GIANT consortium, Tsunoda T, Yamamoto K, Nakamura Y, Kamatani N, Tanaka T

Abstract

Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide problem. Although multiple genetic loci associated with body mass index, the most common measure of obesity, have been identified in European populations, few studies have focused on Asian populations. Here we report a genome-wide association study and replication studies with 62,245 east Asian subjects, which identified two new body mass index-associated loci in the CDKAL1 locus at 6p22 (rs2206734, P = 1.4 × 10(-11)) and the KLF9 locus at 9q21 (rs11142387, P = 1.3 × 10(-9)), as well as several previously reported loci (the SEC16B, BDNF, FTO, MC4R and GIPR loci, P < 5.0 × 10(-8)). We subsequently performed gene-gene interaction analyses and identified an interaction (P = 2.0 × 10(-8)) between a SNP in the KLF9 locus (rs11142387) and one in the MSTN (also known as GDF8) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity.

MeSH Terms
Asians/genetics Body Mass Index Chromosomes, Human, Pair 6/genetics Chromosomes, Human, Pair 9/genetics Cyclin-Dependent Kinase 5/genetics Far East Genetic Variation Genome-Wide Association Study Genotype Humans Kruppel-Like Transcription Factors/genetics Obesity/ethnology,genetics Polymorphism, Single Nucleotide/genetics tRNA Methyltransferases
Chemicals
KLF9 protein, human Kruppel-Like Transcription Factors tRNA Methyltransferases Cyclin-Dependent Kinase 5 CDKAL1 protein, human
Authors & Affiliations
20 authors, click to expand affiliations / ORCID
Okada Yukinori
Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Yokohama, Japan. [email protected]
Kubo Michiaki
Ohmiya Hiroko
Takahashi Atsushi
Kumasaka Natsuhiko
Hosono Naoya
Maeda Shiro
Wen Wanqing
Dorajoo Rajkumar
Go Min Jin
Zheng Wei
Kato Norihiro
Wu Jer-Yuarn
Lu Qi
GIANT consortium
Tsunoda Tatsuhiko
Yamamoto Kazuhiko
Nakamura Yusuke
Kamatani Naoyuki
Tanaka Toshihiro
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1546-1718
DOI
10.1038/ng.1086
Email
[email protected]
Published
2012-02-19
Epub
2012-00-19
Pages
302-6
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC3838874
Subset
IM
Grants
NCI NIH HHS · R01 CA064277 · United States
NCI NIH HHS · R01 CA148667 · United States
NHLBI NIH HHS · R01 HL090682 · United States
NHLBI NIH HHS · R01 HL087263 · United States
NHLBI NIH HHS · U01 HL072507 · United States
External Links
PubMed source DOI: 10.1038/ng.1086 PMC Full Text View journal details
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