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PMID: 22395773 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Sirtuins as regulators of metabolism and healthspan.

Nature reviews. Molecular cell biology ·Vol. 13 ·No. 4 ·2012-03-07 ·Pages 225-238

Houtkooper RH, Pirinen E, Auwerx J

Abstract

Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1-SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in different cellular compartments: they deacetylate histones and several transcriptional regulators in the nucleus, but also specific proteins in other cellular compartments, such as in the cytoplasm and in mitochondria. As a consequence, sirtuins regulate fat and glucose metabolism in response to physiological changes in energy levels, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan.

MeSH Terms
Aging/genetics,metabolism Animals Energy Metabolism Glucose/metabolism Histones/genetics,metabolism Homeostasis Humans Insulin/metabolism Insulin Secretion Lipid Metabolism Longevity/genetics Multigene Family NAD/metabolism Phylogeny Protein Processing, Post-Translational Resveratrol Sirtuins/physiology Stilbenes/pharmacology
Chemicals
Histones Insulin Stilbenes NAD Sirtuins Glucose Resveratrol
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Houtkooper Riekelt H
Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Pirinen Eija
Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. | Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland.
Auwerx Johan
Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm3293
Published
2012-03-07
Epub
2012-00-07
Pages
225-238
Language
English
Region
England
NLM ID
100962782
PMCID
PMC4872805
Subset
IM
Grants
European Research Council · 231138 · International
External Links
PubMed source DOI: 10.1038/nrm3293 PMC Full Text View journal details
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