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PMID: 22427188 Published · ppublish English Journal Article Review

SNARE requirements en route to exocytosis: from many to few.

Journal of molecular neuroscience : MN ·Vol. 48 ·No. 2 ·2012-10-00 ·Pages 387-94

Mohrmann R, Sørensen JB

Abstract

Although it has been known for almost two decades that the ternary complex of N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) constitutes the functional unit driving membrane fusion, our knowledge about the dynamical arrangement and organization of SNARE proteins and their complexes before and during vesicle exocytosis is still limited. Here, we review recent progress in this expanding field with emphasis on the question of fusion complex stoichiometry, i.e., how many SNARE proteins and complexes are needed for the fusion of a vesicle with the plasma membrane.

MeSH Terms
Animals Chromaffin Cells/physiology Exocytosis/physiology Humans Membrane Fusion/physiology Neurosecretory Systems/cytology,physiology SNARE Proteins/physiology
Chemicals
SNARE Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mohrmann Ralf
Department of Physiology, University of Saarland, Homburg, Germany. [email protected]
Sørensen Jakob B
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Article Info
Journal
Journal of molecular neuroscience : MN
Abbr.
J Mol Neurosci
ISSN
1559-1166
DOI
10.1007/s12031-012-9744-2
Email
[email protected]
Published
2012-10-00
Epub
2012-00-17
Pages
387-94
Language
English
Region
United States
NLM ID
9002991
Subset
IM
External Links
PubMed source DOI: 10.1007/s12031-012-9744-2 View journal details
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