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PMID: 22569552 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Tet family proteins and 5-hydroxymethylcytosine in development and disease.

Development (Cambridge, England) ·Vol. 139 ·No. 11 ·2012-06-00 ·Pages 1895-902

Tan L, Shi YG

Abstract

Over the past few decades, DNA methylation at the 5-position of cytosine (5-methylcytosine, 5mC) has emerged as an important epigenetic modification that plays essential roles in development, aging and disease. However, the mechanisms controlling 5mC dynamics remain elusive. Recent studies have shown that ten-eleven translocation (Tet) proteins can catalyze 5mC oxidation and generate 5mC derivatives, including 5-hydroxymethylcytosine (5hmC). The exciting discovery of these novel 5mC derivatives has begun to shed light on the dynamic nature of 5mC, and emerging evidence has shown that Tet family proteins and 5hmC are involved in normal development as well as in many diseases. In this Primer we provide an overview of the role of Tet family proteins and 5hmC in development and cancer.

MeSH Terms
5-Methylcytosine/analogs & derivatives Animals Cytosine/analogs & derivatives,chemistry,metabolism DNA Methylation/genetics DNA-Binding Proteins/chemistry,genetics,metabolism Embryonic Development/genetics Epigenesis, Genetic/genetics Humans Mice Mice, Knockout Molecular Structure Multigene Family/genetics Neoplasms/genetics Oxidation-Reduction Protein Structure, Tertiary Proto-Oncogene Proteins/chemistry,genetics,metabolism
Chemicals
DNA-Binding Proteins Proto-Oncogene Proteins TET1 protein, mouse 5-hydroxymethylcytosine 5-Methylcytosine Cytosine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tan Li
Laboratory of Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PR China.
Shi Yujiang Geno
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Article Info
Journal
Development (Cambridge, England)
Abbr.
Development
ISSN
1477-9129
DOI
10.1242/dev.070771
Published
2012-06-00
Pages
1895-902
Language
English
Region
England
NLM ID
8701744
PMCID
PMC3347683
Subset
IM
External Links
PubMed source DOI: 10.1242/dev.070771 PMC Full Text View journal details
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