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PMID: 22578495 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

A-to-I RNA editing: effects on proteins key to neural excitability.

Neuron ·Vol. 74 ·No. 3 ·2012-05-10 ·Pages 432-9

Rosenthal JJ, Seeburg PH

Abstract

RNA editing by adenosine deamination is a process used to diversify the proteome. The expression of ADARs, the editing enzymes, is ubiquitous among true metazoans, and so adenosine deamination is thought to be universal. By changing codons at the level of mRNA, protein function can be altered, perhaps in response to physiological demand. Although the number of editing sites identified in recent years has been rising exponentially, their effects on protein function, in general, are less well understood. This review assesses the state of the field and highlights particular cases where the biophysical alterations and functional effects caused by RNA editing have been studied in detail.

MeSH Terms
Adenosine/genetics,metabolism Animals Biophysical Phenomena/genetics Humans Ion Channels Models, Biological Neurons/physiology Proteins/genetics,metabolism RNA Editing RNA, Messenger/genetics,metabolism
Chemicals
Ion Channels Proteins RNA, Messenger Adenosine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rosenthal Joshua J C
Institute of Neurobiology and Department of Biochemistry, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico 00901, USA.
Seeburg Peter H
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Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
1097-4199
DOI
10.1016/j.neuron.2012.04.010
Published
2012-05-10
Pages
432-9
Language
English
Region
United States
NLM ID
8809320
PMCID
PMC3724421
Subset
IM
Grants
NCRR NIH HHS · G12 RR003051 · United States
NINDS NIH HHS · R01 NS064259 · United States
NCRR NIH HHS · G12 RR 03051 · United States
External Links
PubMed source DOI: 10.1016/j.neuron.2012.04.010 PMC Full Text View journal details
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