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PMID: 226987 Published · ppublish English Journal Article

Effect of interferon on concentrations of cyclic nucleotides in cultured cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 8 ·1979-08-00 ·Pages 3890-3

Tovey MG, Rochette-Egly C, Castagna M

Abstract

Constant intracellular concentrations of both adenosine 3',5'-cyclic-monophosphate (cyclic AMP) and guanosine 3',5'-cyclic-monophosphate (cyclic GMP) were obtained when leukemia L1210 cells were cultivated under steady-state conditions in the chemostat. In this sensitive and controlled system addition of mouse interferon resulted in a rapid (5-10 min) increase in the intracellular concentration of cyclic GMP, which preceded by several hours an increase in the intracellular concentration of cyclic AMP. In contrast to the effect of interferon, addition of prostaglandin E1 induced a rapid increase in the intracellular concentration of cyclic AMP without markedly affecting the intracellular concentration of cyclic GMP. It is suggested that the rapid effect of interferon on cyclic GMP plays a role in mediating some of the effects of interferon on cells.

MeSH Terms
Animals Cell Division/drug effects Cells, Cultured/drug effects Cyclic AMP/metabolism Cyclic GMP/metabolism Interferons/pharmacology Leukemia L1210/metabolism Mice Nucleotides, Cyclic/metabolism Prostaglandins E/pharmacology
Chemicals
Nucleotides, Cyclic Prostaglandins E Interferons Cyclic AMP Cyclic GMP
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tovey M G
Rochette-Egly C
Castagna M
References (35)
35 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.8.3890
Published
1979-08-00
Pages
3890-3
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC383941
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.8.3890 PMC Full Text View journal details
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