Physical, morphological, and biochemical alterations in the membrane of AKR mouse cells after interferon treatment.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 4 ·1978-04-00 ·Pages 1859-63

Chang EH, Jay FT, Friedman RM

Abstract

Interferon treatment of AKR,C- cells was followed by the establishment of an antiviral state and apparently concomitant morphological, physical, and biochemical alterations of the cell plasma membrane. The density of the plasma membrane was significant altered, and the concentration of some plasma membrane glycoproteins and the number of intramembranous particles observed in freeze-fracture electron micrographs were increased. A parallel increase in the concentration of intramembranous particles and the resistance to viral infection during interferon treatment as well as their parallel decrease upon removal of interferon suggests a relationship between the particle density and the establishment of the antiviral state.

MeSH Terms

Animals Cell Line Cell Membrane/drug effects,metabolism,ultrastructure Centrifugation, Density Gradient Electrophoresis, Polyacrylamide Gel Glucosamine/metabolism Glycoproteins/metabolism Interferons/pharmacology Membrane Proteins/metabolism Mice Time Factors

Chemicals

Glycoproteins Membrane Proteins Interferons Glucosamine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Chang E H

Jay F T

Friedman R M

References (25)

25 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.75.4.1859

Published

1978-04-00

Pages

1859-63

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC392440

Subset

External Links

PubMed source DOI: 10.1073/pnas.75.4.1859 PMC Full Text View journal details

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Physical, morphological, and biochemical alterations in the membrane of AKR mouse cells after interferon treatment.

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