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PMID: 22717528 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Modeling neurodevelopmental disorders using human neurons.

Current opinion in neurobiology ·Vol. 22 ·No. 5 ·2012-10-00 ·Pages 785-90

Chailangkarn T, Acab A, Muotri AR

Abstract

The cellular and molecular mechanisms of neurodevelopmental conditions such as autism spectrum disorders have been studied intensively for decades. The unavailability of live patient neurons for research, however, has represented a major obstacle in the elucidation of the disease etiologies. Recently, the development of induced pluripotent stem cell (iPSC) technology allows for the generation of human neurons from somatic cells of patients. We review ongoing studies using iPSCs as an approach to model neurodevelopmental disorders, the promise and caveats of this technique and its potential for drug screening. The reproducible findings of relevant phenotypes in Rett syndrome iPSC-derived neurons suggest that iPSC technology offers a novel and unique opportunity for the understanding of and the development of therapeutics for other autism spectrum disorders.

MeSH Terms
Cell Differentiation/physiology Central Nervous System Diseases/complications,pathology,therapy Developmental Disabilities/complications,pathology,therapy Humans Induced Pluripotent Stem Cells/physiology Neurons/physiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chailangkarn Thanathom
University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, USA.
Acab Allan
Muotri Alysson Renato
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Article Info
Journal
Current opinion in neurobiology
Abbr.
Curr Opin Neurobiol
ISSN
1873-6882
DOI
10.1016/j.conb.2012.04.004
Published
2012-10-00
Epub
2012-00-19
Pages
785-90
Language
English
Region
England
NLM ID
9111376
PMCID
PMC3587787
Subset
IM
Grants
NIH HHS · 1-DP2-OD006495-01 · United States
NIH HHS · DP2 OD006495 · United States
NIMH NIH HHS · R01 MH094753 · United States
NICHD NIH HHS · P01 HD033113 · United States
NIMH NIH HHS · R21 MH093954-01A1 · United States
NIMH NIH HHS · R21 MH093954 · United States
NIMH NIH HHS · 1R21MH093954 · United States
NICHD NIH HHS · P01 HD33113 · United States
NIH HHS · DP2 OD006495-01 · United States
NINDS NIH HHS · N01NS22343 · United States
NIGMS NIH HHS · T32 GM008666 · United States
NIMH NIH HHS · R01 MH094753-02 · United States
External Links
PubMed source DOI: 10.1016/j.conb.2012.04.004 PMC Full Text View journal details
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