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PMID: 22740325 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships.

Human genetics ·Vol. 131 ·No. 10 ·2012-10-00 ·Pages 1565-89

Cortessis VK, Thomas DC, Levine AJ, Breton CV, Mack TM, Siegmund KD, Haile RW, Laird PW

Abstract

Changes in epigenetic marks such as DNA methylation and histone acetylation are associated with a broad range of disease traits, including cancer, asthma, metabolic disorders, and various reproductive conditions. It seems plausible that changes in epigenetic state may be induced by environmental exposures such as malnutrition, tobacco smoke, air pollutants, metals, organic chemicals, other sources of oxidative stress, and the microbiome, particularly if the exposure occurs during key periods of development. Thus, epigenetic changes could represent an important pathway by which environmental factors influence disease risks, both within individuals and across generations. We discuss some of the challenges in studying epigenetic mediation of pathogenesis and describe some unique opportunities for exploring these phenomena.

MeSH Terms
Animals Environmental Exposure Epigenesis, Genetic Epigenomics Gene-Environment Interaction Genetic Predisposition to Disease Genomics Humans
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Cortessis Victoria K
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA.
Thomas Duncan C
Levine A Joan
Breton Carrie V
Mack Thomas M
Siegmund Kimberly D
Haile Robert W
Laird Peter W
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
1432-1203
DOI
10.1007/s00439-012-1189-8
Published
2012-10-00
Epub
2012-00-28
Pages
1565-89
Language
English
Region
Germany
NLM ID
7613873
PMCID
PMC3432200
Subset
IM
Grants
NIEHS NIH HHS · P30 ES007048 · United States
NIEHS NIH HHS · R56 ES017091 · United States
NIEHS NIH HHS · R01 ES019876 · United States
NCI NIH HHS · P30 CA014089 · United States
NIEHS NIH HHS · P30 ES 07048 · United States
NIEHS NIH HHS · R21 ES020794 · United States
External Links
PubMed source DOI: 10.1007/s00439-012-1189-8 PMC Full Text View journal details
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