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PMID: 22777127 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Genetic architectures of psychiatric disorders: the emerging picture and its implications.

Nature reviews. Genetics ·Vol. 13 ·No. 8 ·2012-07-10 ·Pages 537-51

Sullivan PF, Daly MJ, O'Donovan M

Abstract

Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5 years, there has been unprecedented progress on the genetics of many of these conditions. In this Review, we discuss the genetics of nine cardinal psychiatric disorders (namely, Alzheimer's disease, attention-deficit hyperactivity disorder, alcohol dependence, anorexia nervosa, autism spectrum disorder, bipolar disorder, major depressive disorder, nicotine dependence and schizophrenia). Empirical approaches have yielded new hypotheses about aetiology and now provide data on the often debated genetic architectures of these conditions, which have implications for future research strategies. Further study using a balanced portfolio of methods to assess multiple forms of genetic variation is likely to yield many additional new findings.

MeSH Terms
Alcoholism/genetics Alzheimer Disease/genetics Anorexia Nervosa/genetics Attention Deficit Disorder with Hyperactivity/genetics Bipolar Disorder/genetics Child Child Development Disorders, Pervasive/genetics Depressive Disorder, Major/genetics Humans Mental Disorders/genetics Models, Genetic Schizophrenia/genetics Tobacco Use Disorder/genetics
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sullivan Patrick F
Departments of Genetics and Psychiatry, CB# 7264, 5097 Genomic Medicine, University of North Carolina at Chapel Hill, North Carolina 27599-27264, USA. [email protected]
Daly Mark J
O'Donovan Michael
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg3240
Email
[email protected]
Published
2012-07-10
Epub
2012-00-10
Pages
537-51
Language
English
Region
England
NLM ID
100962779
PMCID
PMC4110909
Subset
IM
Grants
NIMH NIH HHS · MH077139 · United States
NIMH NIH HHS · U01 MH085520 · United States
Medical Research Council · G0801418 · United Kingdom
NIMH NIH HHS · R01 MH077139 · United States
NIMH NIH HHS · MH085520 · United States
Medical Research Council · G0800509 · United Kingdom
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1038/nrg3240 PMC Full Text View journal details
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