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PMID: 22828004 Published · ppublish English Journal Article Multicenter Study Randomized Controlled Trial Research Support, N.I.H., Extramural

The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables.

Journal of glaucoma ·Vol. 22 ·No. 7 ·2013-09-00 ·Pages 517-25

Wiggs JL, Hauser MA, Abdrabou W, Allingham RR, Budenz DL, Delbono E, Friedman DS, Kang JH, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Loomis S, Liu Y, McCarty C, Medeiros FA, Moroi SE, Olson LM, Realini A, Richards JE, Rozsa FW, Schuman JS, Singh K, Stein JD, Vollrath D, Weinreb RN, Wollstein G, Yaspan BL, Yoneyama S, Zack D, Zhang K, Pericak-Vance M, Pasquale LR, Haines JL

Abstract

Primary open-angle glaucoma (POAG) is a common disease with complex inheritance. The identification of genes predisposing to POAG is an important step toward the development of novel gene-based methods of diagnosis and treatment. Genome-wide association studies (GWAS) have successfully identified genes contributing to complex traits such as POAG however, such studies frequently require very large sample sizes, and thus, collaborations and consortia have been of critical importance for the GWAS approach. In this report we describe the formation of the NEIGHBOR consortium, the harmonized case control definitions used for a POAG GWAS, the clinical features of the cases and controls, and the rationale for the GWAS study design.

MeSH Terms
Adult Aged Aged, 80 and over Antihypertensive Agents/therapeutic use Case-Control Studies Cooperative Behavior Female Gene Expression Profiling Genetic Predisposition to Disease Genome-Wide Association Study Genotype Glaucoma, Open-Angle/diagnosis,genetics,therapy Humans Intraocular Pressure Male Middle Aged Research Design Trabeculectomy
Chemicals
Antihypertensive Agents
Authors & Affiliations
34 authors, click to expand affiliations / ORCID
Wiggs Janey L
Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. [email protected]
Hauser Michael A
Abdrabou Wael
Allingham Robert Rand
Budenz Donald L
Delbono Elizabeth
Friedman David S
Kang Jae H
Gaasterland Douglas
Gaasterland Terry
Lee Richard K
Lichter Paul R
Loomis Stephanie
Liu Yutao
McCarty Cathy
Medeiros Felipe A
Moroi Sayoko E
Olson Lana M
Realini Anthony
Richards Julia E
Rozsa Frank W
Schuman Joel S
Singh Kuldev
Stein Joshua D
Vollrath Douglas
Weinreb Robert N
Wollstein Gadi
Yaspan Brian L
Yoneyama Sachiko
Zack Don
Zhang Kang
Pericak-Vance Margaret
Pasquale Louis R
Haines Jonathan L
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Article Info
Journal
Journal of glaucoma
Abbr.
J Glaucoma
ISSN
1536-481X
DOI
10.1097/IJG.0b013e31824d4fd8
Email
[email protected]
Published
2013-09-00
Pages
517-25
Language
English
Region
United States
NLM ID
9300903
PMCID
PMC3485429
Subset
IM
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External Links
PubMed source DOI: 10.1097/IJG.0b013e31824d4fd8 PMC Full Text View journal details
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