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PMID: 22919601 Published · epublish English Journal Article Review

Glycoconjugates play a key role in Campylobacter jejuni Infection: interactions between host and pathogen.

Frontiers in cellular and infection microbiology ·Vol. 2 ·2012-00-00 ·Pages 9

Day CJ, Semchenko EA, Korolik V

Abstract

Glycan based interactions between host and pathogen are critical in many bacterial and viral diseases. Glycan interactions range from initial receptor based adherence to protecting the infective agent from the host's immune response through molecular mimicry. Campylobacter jejuni is an ideal model for studying the role of glycans in host-pathogen interactions, as well as the role of bacterial surface glycoconjugates in infection. Using glycan array analysis, C. jejuni has been shown to interact with a wide range of host glycoconjugates. Mannose and sialic acid residues appear to play a role in initial interactions between host and pathogen following environmental exposure, whereas fucose and galactose based interactions are likely to be required for prolonged colonization. Other studies have highlighted potential decoy receptor type interactions between host's intestinal mucins and C. jejuni, demonstrating the importance of host glycoproteins as defense against C. jejuni infection as well as the role for glycoconjugates found in human breast milk in protection of breast feeding infants from infection with C. jejuni. C. jejuni can produce N- and O-linked glycoproteins, capsular polysaccharide (CPS) and/or lipooligosaccharide (LOS) which results in C. jejuni presenting its own diverse sugar coated displays on the cell surface. Bacterial glycans play an important and versatile role in infection and disease. Of these, the best understood is the molecular mimicry of human gangliosides presented by C. jejuni's LOS and its link to the onset of autoimmune neuropathies such as the Guillain Barrè syndrome (GBS). However, the role of glycoconjugates presented by C. jejuni extends beyond expression of sialylated ganglioside structures involved in initiation of GBS. Expression of surface glycans by C. jejuni may also relate to the ability of this organism to interact with the glycoproteins for initial host-pathogen interactions and continued infectivity.

Keywords
LOS glycans glycoconjugates
MeSH Terms
Autoimmune Diseases/immunology,microbiology Bacterial Adhesion Campylobacter Infections/immunology,microbiology Campylobacter jejuni/chemistry,immunology,pathogenicity Glycoconjugates/chemistry,immunology,metabolism Host-Pathogen Interactions Humans Virulence Factors/chemistry,immunology,metabolism
Chemicals
Glycoconjugates Virulence Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Day Christopher James
Institute for Glycomics, Griffith University, Gold Coast QLD, Australia.
Semchenko Evgeny Alexander
Korolik Victoria
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Article Info
Journal
Frontiers in cellular and infection microbiology
Abbr.
Front Cell Infect Microbiol
ISSN
2235-2988
DOI
10.3389/fcimb.2012.00009
Published
2012-00-00
Epub
2012-00-14
Pages
9
Language
English
Region
Switzerland
NLM ID
101585359
PMCID
PMC3417407
Subset
IM
External Links
PubMed source DOI: 10.3389/fcimb.2012.00009 PMC Full Text View journal details
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