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PMID: 23084079 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

On the nature of mycobacteriophage diversity and host preference.

Virology ·Vol. 434 ·No. 2 ·2012-12-20 ·Pages 187-201

Jacobs-Sera D, Marinelli LJ, Bowman C, Broussard GW, Guerrero Bustamante C, Boyle MM, Petrova ZO, Dedrick RM, Pope WH, Science Education Alliance Phage Hunters Advancing Genomics And Evolutionary Science Sea-Phages Program, Modlin RL, Hendrix RW, Hatfull GF

Abstract

The complete genome sequences of over 220 mycobacteriophages reveal them to be highly diverse, with numerous types sharing little or no nucleotide sequence identity with each other. We have determined the preferences of these phages for Mycobacterium tuberculosis and for other strains of Mycobacterium smegmatis, and find there is a correlation between genome type (cluster, subcluster, singleton) and host range. For many of the phages, expansion of host range occurs at relatively high frequencies, and we describe several examples in which host constraints occur at early stages of infection (adsorption or DNA injection), and phages have the ability to expand their host range through mutations in tail genes. We present a model in which phage diversity is a function of both the ability of phages to rapidly adapt to new hosts and the richness of the diversity of the bacterial population from which those phages are isolated.

MeSH Terms
Cluster Analysis Genetic Variation Genome, Viral Genotype Host Specificity Mycobacteriophages/classification,genetics,physiology Mycobacterium smegmatis/virology Mycobacterium tuberculosis/virology
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Jacobs-Sera Deborah
Pittsburgh Bacteriophage Institute, Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Marinelli Laura J
Bowman Charles
Broussard Gregory W
Guerrero Bustamante Carlos
Boyle Michelle M
Petrova Zaritza O
Dedrick Rebekah M
Pope Welkin H
Science Education Alliance Phage Hunters Advancing Genomics And Evolutionary Science Sea-Phages Program
Modlin Robert L
Hendrix Roger W
Hatfull Graham F
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Article Info
Journal
Virology
Abbr.
Virology
ISSN
1096-0341
DOI
10.1016/j.virol.2012.09.026
Published
2012-12-20
Epub
2012-00-22
Pages
187-201
Language
English
Region
United States
NLM ID
0110674
PMCID
PMC3518647
Subset
IM
Grants
NIGMS NIH HHS · GM093901 · United States
NIAMS NIH HHS · R21 AR060382 · United States
Howard Hughes Medical Institute · United States
NCRR NIH HHS · P20 RR016461 · United States
NIGMS NIH HHS · R24 GM093901 · United States
NIAMS NIH HHS · R21AR060382 · United States
External Links
PubMed source DOI: 10.1016/j.virol.2012.09.026 PMC Full Text
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