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PMID: 23332744 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

A decade of riboswitches.

Cell ·Vol. 152 ·No. 1-2 ·2013-01-17 ·Pages 17-24

Serganov A, Nudler E

Abstract

Riboswitches were discovered in 2002 in bacteria as RNA-based intracellular sensors of vitamin derivatives. During the last decade, naturally occurring RNA sensor elements have been found to bind a range of small metabolites and ions and to exert regulatory control of transcription, translation, splicing, and RNA stability. Extensive biochemical, structural, and genetic studies have established the basic principles underpinning riboswitch function in all three kingdoms of life with implications for developing antibiotics, designing new molecular sensors, and integrating riboswitches into synthetic circuits.

MeSH Terms
Alternative Splicing Bacteria/genetics Gene Expression Regulation Nucleic Acid Conformation RNA/chemistry,genetics,metabolism Riboswitch
Chemicals
Riboswitch RNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Serganov Alexander
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA. [email protected]
Nudler Evgeny
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2012.12.024
Email
[email protected]
Published
2013-01-17
Pages
17-24
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC4215550
Subset
IM
Grants
NIAID NIH HHS · R01 AI090110 · United States
NIGMS NIH HHS · R01 GM058750 · United States
External Links
PubMed source DOI: 10.1016/j.cell.2012.12.024 PMC Full Text View journal details
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