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PMID: 23423530 Published · ppublish English Journal Article Review

Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences.

Cellular and molecular life sciences : CMLS ·Vol. 70 ·No. 20 ·2013-10-00 ·Pages 3813-27

Pillay J, Tak T, Kamp VM, Koenderman L

Abstract

Neutrophils are essential effector cells in the host defense against invading pathogens. Recently, novel neutrophil functions have emerged in addition to their classical anti-microbial role. One of these functions is the suppression of T cell responses. In this respect, neutrophils share similarities with granulocytic myeloid-derived suppressor cells (G-MDSCs). In this review, we will discuss the similarities and differences between neutrophils and G-MDSCs. Various types of G-MDSCs have been described, ranging from immature to mature cells shaping the immune response by different immune suppressive mechanisms. However, all types of G-MDSCs share distinct features of neutrophils, such as surface markers and morphology. We propose that G-MDSCs are heterogeneous and represent novel phenotypes of neutrophils, capable of suppressing the immune response. In this review, we will attempt to clarify the differences and similarities between neutrophils and G-MDSCs and attempt to facilitate further research.

MeSH Terms
Animals Cell Communication Cell Differentiation Granulocytes/cytology,immunology Humans Immune Tolerance Immunological Synapses Inflammation/immunology,pathology Lymph Nodes/cytology,immunology Neutrophil Activation Neutrophils/immunology Phenotype Reactive Oxygen Species/metabolism Spleen/cytology,immunology
Chemicals
Reactive Oxygen Species
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Pillay Janesh
Department of Respiratory Medicine, University Medical Center Utrecht, HP. E 03.511, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Tak Tamar
Kamp Vera M
Koenderman Leo
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Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-9071
DOI
10.1007/s00018-013-1286-4
Published
2013-10-00
Epub
2013-00-20
Pages
3813-27
Language
English
Region
Switzerland
NLM ID
9705402
PMCID
PMC3781313
Subset
IM
External Links
PubMed source DOI: 10.1007/s00018-013-1286-4 PMC Full Text View journal details
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