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PMID: 234419 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Marker discrimination in deoxyribonucleic acid-mediated transformation of various Pneumococcus strains.

Journal of bacteriology ·Vol. 121 ·No. 2 ·1975-02-00 ·Pages 608-18

Tiraby G, Fox MS, Bernheimer H

Abstract

The function responsible for discrimination among markers (point mutations) in Pneumococcus (hex) was traced back to the early strains used to demonstrate the chemical basis of transformation in the early 1940s. Those currently used laboratory strains failing to manifest this function arose from a single subline of the original strain. The function was also evident in other independently isolated strains including a number of different serological types. The hex function was not evident in transformation between heterologous pneumococcal strains probably as a result of the sensitivity of the function to saturation in the presence of deoxyribonucleic acid from closely related but nonisogenic strains.

MeSH Terms
Anti-Bacterial Agents/pharmacology Bacillus subtilis DNA, Bacterial Drug Resistance, Microbial Fusidic Acid/pharmacology Genes Genetic Variation Hybridization, Genetic Mutation Phenotype Rifampin/pharmacology Streptococcus Streptococcus pneumoniae/drug effects Streptomycin/pharmacology Sulfanilamides/pharmacology Transformation, Genetic
Chemicals
Anti-Bacterial Agents DNA, Bacterial Sulfanilamides Fusidic Acid Rifampin Streptomycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tiraby G
Fox M S
Bernheimer H
References (19)
19 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.121.2.608-618.1975
Published
1975-02-00
Pages
608-18
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC245973
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.121.2.608-618.1975 PMC Full Text View journal details
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