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PMID: 23636397 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Using membrane transporters to improve crops for sustainable food production.

Nature ·Vol. 497 ·No. 7447 ·2013-05-02 ·Pages 60-6

Schroeder JI, Delhaize E, Frommer WB, Guerinot ML, Harrison MJ, Herrera-Estrella L, Horie T, Kochian LV, Munns R, Nishizawa NK, Tsay YF, Sanders D

Abstract

With the global population predicted to grow by at least 25 per cent by 2050, the need for sustainable production of nutritious foods is critical for human and environmental health. Recent advances show that specialized plant membrane transporters can be used to enhance yields of staple crops, increase nutrient content and increase resistance to key stresses, including salinity, pathogens and aluminium toxicity, which in turn could expand available arable land.

MeSH Terms
Agriculture/methods Aluminum/toxicity Biological Transport Cell Wall/metabolism Conservation of Natural Resources Crops, Agricultural/drug effects,genetics,metabolism,microbiology Food Supply/statistics & numerical data Genetic Engineering Humans Iron/metabolism Membrane Transport Proteins/genetics,metabolism Nitrates/metabolism Nutritive Value Phosphates/metabolism Public Health Salinity Sodium/toxicity Soil/chemistry Sucrose/metabolism Zinc/metabolism
Chemicals
Membrane Transport Proteins Nitrates Phosphates Soil Sucrose Sodium Aluminum Iron Zinc
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Schroeder Julian I
Division of Biological Sciences, Food and Fuel for the 21st Century Center, University of California San Diego, La Jolla, California 92093-0116, USA. [email protected]
Delhaize Emmanuel
Frommer Wolf B
Guerinot Mary Lou
Harrison Maria J
Herrera-Estrella Luis
Horie Tomoaki
Kochian Leon V
Munns Rana
Nishizawa Naoko K
Tsay Yi-Fang
Sanders Dale
References (82)
82 references, click to expand
  1. An aluminum-activated citrate transporter in barley.
    Plant Cell Physiol. 2007 Aug;48(8):1081-91 PMID: 17634181
  2. FUNCTION AND MECHANISM OF ORGANIC ANION EXUDATION FROM PLANT ROOTS.
    Annu Rev Plant Physiol Plant Mol Biol. 2001 Jun;52:527-560 PMID: 11337408
  3. Structure and transport mechanism of a high-affinity potassium uptake transporter from higher plants.
    Nature. 1994 Aug 25;370(6491):655-8 PMID: 8065452
  4. Nitrogen economics of root foraging: transitive closure of the nitrate-cytokinin relay and distinct systemic signaling for N supply vs. demand.
    Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18524-9 PMID: 22025711
  5. ABC transporter AtABCG25 is involved in abscisic acid transport and responses.
    Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2361-6 PMID: 20133881
  6. High-efficiency TALEN-based gene editing produces disease-resistant rice.
    Nat Biotechnol. 2012 May 07;30(5):390-2 PMID: 22565958
  7. Activation of Rice nicotianamine synthase 2 (OsNAS2) enhances iron availability for biofortification.
    Mol Cells. 2012 Mar;33(3):269-75 PMID: 22228185
  8. A novel iron-regulated metal transporter from plants identified by functional expression in yeast.
    Proc Natl Acad Sci U S A. 1996 May 28;93(11):5624-8 PMID: 8643627
  9. Sugar transporters for intercellular exchange and nutrition of pathogens.
    Nature. 2010 Nov 25;468(7323):527-32 PMID: 21107422
  10. Na/H Antiport in Isolated Tonoplast Vesicles from Storage Tissue of Beta vulgaris.
    Plant Physiol. 1985 May;78(1):163-7 PMID: 16664191
  11. Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants.
    Dev Cell. 2010 Jun 15;18(6):927-37 PMID: 20627075
  12. The Arabidopsis nitrate transporter NRT2.4 plays a double role in roots and shoots of nitrogen-starved plants.
    Plant Cell. 2012 Jan;24(1):245-58 PMID: 22227893
  13. Gene limiting cadmium accumulation in rice.
    Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16500-5 PMID: 20823253
  14. PHLOEM UNLOADING: Sieve Element Unloading and Post-Sieve Element Transport.
    Annu Rev Plant Physiol Plant Mol Biol. 1997 Jun;48:191-222 PMID: 15012262
  15. A chloroplast phosphate transporter, PHT2;1, influences allocation of phosphate within the plant and phosphate-starvation responses.
    Plant Cell. 2002 Aug;14(8):1751-66 PMID: 12172020
  16. Rice endosperm iron biofortification by targeted and synergistic action of nicotianamine synthase and ferritin.
    Plant Biotechnol J. 2009 Sep;7(7):631-44 PMID: 19702755
  17. Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters.
    Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21187-92 PMID: 21078981
  18. The putative high-affinity nitrate transporter NRT2.1 represses lateral root initiation in response to nutritional cues.
    Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13693-8 PMID: 16157886
  19. Rice xa13 recessive resistance to bacterial blight is defeated by induction of the disease susceptibility gene Os-11N3.
    Plant Cell. 2010 Nov;22(11):3864-76 PMID: 21098734
  20. The protein kinase Pstol1 from traditional rice confers tolerance of phosphorus deficiency.
    Nature. 2012 Aug 23;488(7412):535-9 PMID: 22914168
  21. Rice metal-nicotianamine transporter, OsYSL2, is required for the long-distance transport of iron and manganese.
    Plant J. 2010 May;62(3):379-90 PMID: 20128878
  22. Rice OsHKT2;1 transporter mediates large Na+ influx component into K+-starved roots for growth.
    EMBO J. 2007 Jun 20;26(12):3003-14 PMID: 17541409
  23. CHL1 functions as a nitrate sensor in plants.
    Cell. 2009 Sep 18;138(6):1184-94 PMID: 19766570
  24. A transcription activator-like effector toolbox for genome engineering.
    Nat Protoc. 2012 Jan 05;7(1):171-92 PMID: 22222791
  25. Altered shoot/root Na+ distribution and bifurcating salt sensitivity in Arabidopsis by genetic disruption of the Na+ transporter AtHKT1.
    FEBS Lett. 2002 Nov 6;531(2):157-61 PMID: 12417304
  26. Shoot Na+ exclusion and increased salinity tolerance engineered by cell type-specific alteration of Na+ transport in Arabidopsis.
    Plant Cell. 2009 Jul;21(7):2163-78 PMID: 19584143
  27. Engineering nitrogen use efficient crop plants: the current status.
    Plant Biotechnol J. 2012 Dec;10(9):1011-25 PMID: 22607381
  28. Two functionally distinct members of the MATE (multi-drug and toxic compound extrusion) family of transporters potentially underlie two major aluminum tolerance QTLs in maize.
    Plant J. 2010 Mar;61(5):728-40 PMID: 20003133
  29. Increased leaf photosynthesis caused by elevated stomatal conductance in a rice mutant deficient in SLAC1, a guard cell anion channel protein.
    J Exp Bot. 2012 Sep;63(15):5635-44 PMID: 22915747
  30. Arabidopsis Pht1;5 mobilizes phosphate between source and sink organs and influences the interaction between phosphate homeostasis and ethylene signaling.
    Plant Physiol. 2011 Jul;156(3):1149-63 PMID: 21628630
  31. A Medicago truncatula phosphate transporter indispensable for the arbuscular mycorrhizal symbiosis.
    Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1720-5 PMID: 17242358
  32. Switching between the two action modes of the dual-affinity nitrate transporter CHL1 by phosphorylation.
    EMBO J. 2003 Mar 3;22(5):1005-13 PMID: 12606566
  33. Gene silencing using the recessive rice bacterial blight resistance gene xa13 as a new paradigm in plant breeding.
    Plant Cell Rep. 2012 May;31(5):851-62 PMID: 22218673
  34. Closing yield gaps through nutrient and water management.
    Nature. 2012 Oct 11;490(7419):254-7 PMID: 22932270
  35. Uptake, allocation and signaling of nitrate.
    Trends Plant Sci. 2012 Aug;17(8):458-67 PMID: 22658680
  36. A tonoplast-localized half-size ABC transporter is required for internal detoxification of aluminum in rice.
    Plant J. 2012 Mar;69(5):857-67 PMID: 22035218
  37. Bio-available zinc in rice seeds is increased by activation tagging of nicotianamine synthase.
    Plant Biotechnol J. 2011 Oct;9(8):865-73 PMID: 21426477
  38. Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron.
    EMBO J. 2005 Dec 7;24(23):4041-51 PMID: 16270029
  39. Salt tolerance conferred by overexpression of a vacuolar Na+/H+ antiport in Arabidopsis.
    Science. 1999 Aug 20;285(5431):1256-8 PMID: 10455050
  40. Localization of iron in Arabidopsis seed requires the vacuolar membrane transporter VIT1.
    Science. 2006 Nov 24;314(5803):1295-8 PMID: 17082420
  41. Iron fortification of rice seeds through activation of the nicotianamine synthase gene.
    Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):22014-9 PMID: 20080803
  42. Metal selectivity determinants in a family of transition metal transporters.
    J Biol Chem. 2012 Jan 27;287(5):3185-96 PMID: 22139846
  43. NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds.
    Nature. 2012 Aug 23;488(7412):531-4 PMID: 22864417
  44. Carbonic anhydrases are upstream regulators of CO2-controlled stomatal movements in guard cells.
    Nat Cell Biol. 2010 Jan;12(1):87-93; sup pp 1-18 PMID: 20010812
  45. Zinc biofortification of cereals: problems and solutions.
    Trends Plant Sci. 2008 Sep;13(9):464-73 PMID: 18701340
  46. The Arabidopsis CHL1 protein plays a major role in high-affinity nitrate uptake.
    Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15134-9 PMID: 9844028
  47. Solutions for a cultivated planet.
    Nature. 2011 Oct 12;478(7369):337-42 PMID: 21993620
  48. Sucrose efflux mediated by SWEET proteins as a key step for phloem transport.
    Science. 2012 Jan 13;335(6065):207-11 PMID: 22157085
  49. Targeting xa13, a recessive gene for bacterial blight resistance in rice.
    Theor Appl Genet. 2006 Feb;112(3):455-61 PMID: 16328230
  50. Rice consumption contributes to arsenic exposure in US women.
    Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20656-60 PMID: 22143778
  51. FRD3, a member of the multidrug and toxin efflux family, controls iron deficiency responses in Arabidopsis.
    Plant Cell. 2002 Aug;14(8):1787-99 PMID: 12172022
  52. Sodium-driven potassium uptake by the plant potassium transporter HKT1 and mutations conferring salt tolerance.
    Science. 1995 Dec 8;270(5242):1660-3 PMID: 7502075
  53. Genetic architecture of aluminum tolerance in rice (Oryza sativa) determined through genome-wide association analysis and QTL mapping.
    PLoS Genet. 2011 Aug;7(8):e1002221 PMID: 21829395
  54. The roles of organic anion permeases in aluminium resistance and mineral nutrition.
    FEBS Lett. 2007 May 25;581(12):2255-62 PMID: 17418140
  55. The role of membrane transport in metabolic engineering of plant primary metabolism.
    Curr Opin Biotechnol. 2013 Apr;24(2):256-62 PMID: 23040411
  56. Over-expression of an Na+-and K+-permeable HKT transporter in barley improves salt tolerance.
    Plant J. 2011 Nov;68(3):468-79 PMID: 21749504
  57. A paralog of the MtN3/saliva family recessively confers race-specific resistance to Xanthomonas oryzae in rice.
    Plant Cell Environ. 2011 Nov;34(11):1958-69 PMID: 21726237
  58. Nonredundant regulation of rice arbuscular mycorrhizal symbiosis by two members of the phosphate transporter1 gene family.
    Plant Cell. 2012 Oct;24(10):4236-51 PMID: 23073651
  59. Promoter mutations of an essential gene for pollen development result in disease resistance in rice.
    Genes Dev. 2006 May 15;20(10):1250-5 PMID: 16648463
  60. A safe operating space for humanity.
    Nature. 2009 Sep 24;461(7263):472-5 PMID: 19779433
  61. Enhanced salt tolerance mediated by AtHKT1 transporter-induced Na unloading from xylem vessels to xylem parenchyma cells.
    Plant J. 2005 Dec;44(6):928-38 PMID: 16359386
  62. AtCIPK8, a CBL-interacting protein kinase, regulates the low-affinity phase of the primary nitrate response.
    Plant J. 2009 Jan;57(2):264-78 PMID: 18798873
  63. Wheat grain yield on saline soils is improved by an ancestral Na⁺ transporter gene.
    Nat Biotechnol. 2012 Mar 11;30(4):360-4 PMID: 22407351
  64. A gene in the multidrug and toxic compound extrusion (MATE) family confers aluminum tolerance in sorghum.
    Nat Genet. 2007 Sep;39(9):1156-61 PMID: 17721535
  65. A rice quantitative trait locus for salt tolerance encodes a sodium transporter.
    Nat Genet. 2005 Oct;37(10):1141-6 PMID: 16155566
  66. Evidence for an essential role of the sucrose transporter in phloem loading and assimilate partitioning.
    EMBO J. 1994 Jan 1;13(1):1-7 PMID: 8306952
  67. The Pht1;9 and Pht1;8 transporters mediate inorganic phosphate acquisition by the Arabidopsis thaliana root during phosphorus starvation.
    New Phytol. 2012 Jul;195(2):356-371 PMID: 22578268
  68. Transporters of arsenite in rice and their role in arsenic accumulation in rice grain.
    Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9931-5 PMID: 18626020
  69. Iron biofortification in rice by the introduction of multiple genes involved in iron nutrition.
    Sci Rep. 2012;2:543 PMID: 22848789
  70. A wheat gene encoding an aluminum-activated malate transporter.
    Plant J. 2004 Mar;37(5):645-53 PMID: 14871306
  71. Engineering phosphorus metabolism in plants to produce a dual fertilization and weed control system.
    Nat Biotechnol. 2012 Sep;30(9):889-93 PMID: 22922674
  72. Ion exchangers NHX1 and NHX2 mediate active potassium uptake into vacuoles to regulate cell turgor and stomatal function in Arabidopsis.
    Plant Cell. 2012 Mar;24(3):1127-42 PMID: 22438021
  73. Functional expression of PHO1 to the Golgi and trans-Golgi network and its role in export of inorganic phosphate.
    Plant J. 2012 Aug;71(3):479-91 PMID: 22449068
  74. The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis.
    Plant Cell. 2009 Oct;21(10):3326-38 PMID: 19861554
  75. A sodium transporter (HKT7) is a candidate for Nax1, a gene for salt tolerance in durum wheat.
    Plant Physiol. 2006 Dec;142(4):1718-27 PMID: 17071645
  76. PDR-type ABC transporter mediates cellular uptake of the phytohormone abscisic acid.
    Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2355-60 PMID: 20133880
  77. Vacuolar membrane transporters OsVIT1 and OsVIT2 modulate iron translocation between flag leaves and seeds in rice.
    Plant J. 2012 Nov;72(3):400-10 PMID: 22731699
  78. Plasma membrane-localized transporter for aluminum in rice.
    Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18381-5 PMID: 20937890
  79. Hydrogen peroxide mediates plant root cell response to nutrient deprivation.
    Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8827-32 PMID: 15173595
  80. Guard cell signal transduction network: advances in understanding abscisic acid, CO2, and Ca2+ signaling.
    Annu Rev Plant Biol. 2010;61:561-91 PMID: 20192751
  81. Transgenic barley (Hordeum vulgare L.) expressing the wheat aluminium resistance gene (TaALMT1) shows enhanced phosphorus nutrition and grain production when grown on an acid soil.
    Plant Biotechnol J. 2009 Jun;7(5):391-400 PMID: 19490502
  82. Ion-beam irradiation, gene identification, and marker-assisted breeding in the development of low-cadmium rice.
    Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19166-71 PMID: 23132948
Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature11909
Email
[email protected]
Published
2013-05-02
Pages
60-6
Language
English
Region
England
NLM ID
0410462
PMCID
PMC3954111
Subset
IM
Grants
NIGMS NIH HHS · R01 GM060396 · United States
NIEHS NIH HHS · P42ES007373 · United States
Howard Hughes Medical Institute · 55005946 · United States
NIGMS NIH HHS · GM078536 · United States
Biotechnology and Biological Sciences Research Council · BB/J004561/1 · United Kingdom
NIEHS NIH HHS · P42 ES007373 · United States
NIGMS NIH HHS · GM060396 · United States
NIEHS NIH HHS · P42ES010337 · United States
NIEHS NIH HHS · P42 ES010337 · United States
NIGMS NIH HHS · R01 GM078536 · United States
External Links
PubMed source DOI: 10.1038/nature11909 PMC Full Text View journal details
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