Home LiteratureArticle Details
PMID: 23989 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Studies of cyclic AMP action using mutant tissue culture cells.

In vitro ·Vol. 14 ·No. 1 ·1978-01-00 ·Pages 140-5

Coffino P, Bourne HR, Insel PA, Melmon KL, Johnson G, Vigne J

Abstract

S49 mouse lymphoma cell mutants, each with a specific defect in its ability to generate or respond to cyclic AMP, have been isolated. Analysis of the properties of these cells has begun to provide information on complex and significant biologic problems related to the cyclic AMP system.

MeSH Terms
Adenylyl Cyclases/metabolism Adrenergic beta-Antagonists/pharmacology Cell Cycle Cell Line Cyclic AMP/metabolism Glucocorticoids/pharmacology Isoproterenol/pharmacology Mitosis Mutation Protein Biosynthesis Protein Kinases/metabolism Receptors, Adrenergic Receptors, Adrenergic, beta
Chemicals
Adrenergic beta-Antagonists Glucocorticoids Receptors, Adrenergic Receptors, Adrenergic, beta Cyclic AMP Protein Kinases Adenylyl Cyclases Isoproterenol
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Coffino P
Bourne H R
Insel P A
Melmon K L
Johnson G
Vigne J
References (19)
19 references, click to expand
  1. Formation and release of a hormone antagonist by rat adipocytes.
    J Biol Chem. 1971 Nov 25;246(22):6822-7 PMID: 4331197
  2. Agonist-specific refractoriness induced by isoproterenol. Studies with mutant cells.
    J Biol Chem. 1976 Dec 10;251(23):7572-6 PMID: 187593
  3. Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes.
    Proc Natl Acad Sci U S A. 1977 Sep;74(9):3715-9 PMID: 198799
  4. Cyclic nucleotide-dependent protein kinases. IV. Widespread occurrence of adenosine 3',5'-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom.
    Proc Natl Acad Sci U S A. 1969 Dec;64(4):1349-55 PMID: 4393915
  5. Independent mechanisms of cyclic AMP and glucocorticoid action.
    Nature. 1977 Jul 14;268(5616):167-9 PMID: 201848
  6. Cyclic AMP, a nonessential regulator of the cell cycle.
    Proc Natl Acad Sci U S A. 1975 Mar;72(3):878-82 PMID: 165491
  7. Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth.
    Science. 1975 Nov 28;190(4217):896-8 PMID: 171770
  8. Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.
    Proc Natl Acad Sci U S A. 1977 May;74(5):2016-20 PMID: 17119
  9. Regulation of protein synthesis by cyclic AMP.
    Adv Cyclic Nucleotide Res. 1974;4(0):335-438 PMID: 4153040
  10. Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase.
    Proc Natl Acad Sci U S A. 1975 Sep;72(9):3735-9 PMID: 1059161
  11. On the nature of hereditable variation in cultured somatic cells.
    Cell. 1976 Jan;7(1):1-11 PMID: 779953
  12. Cyclic AMP-induced cytolysis in S49 cells: selection of an unresponsive "deathless" mutant.
    Cell. 1977 May;11(1):149-55 PMID: 194702
  13. Cyclic nucleotides in cultured cells.
    Adv Cyclic Nucleotide Res. 1975;6:245-338 PMID: 171929
  14. Beta adrenergic receptors and adenylate cyclase: products of separate genes?
    Mol Pharmacol. 1976 Nov;12(6):1062-9 PMID: 187924
  15. The role of cyclic nucleotides in the cell cycle.
    Adv Cyclic Nucleotide Res. 1976;7:69-114 PMID: 188318
  16. Genetic approaches to steroid hormone action.
    Recent Prog Horm Res. 1976;32:3-32 PMID: 183244
  17. Restoration of sensitivity of cultured hepatoma cells to cyclic nucleotides shows permissive effect of dexamethasone.
    Nature. 1976 Feb 19;259(5544):572-3 PMID: 2876
  18. Regulation of adenylate cyclase-coupled beta adrenergic receptor binding sites by beta adrenergic catecholamines in vitro.
    Mol Pharmacol. 1976 May;12(3):409-19 PMID: 934056
  19. Selection of a variant lymphoma cell deficient in adenylate cyclase.
    Science. 1975 Feb 28;187(4178):750-2 PMID: 163487
Article Info
Journal
In vitro
Abbr.
In Vitro
ISSN
0073-5655
DOI
10.1007/BF02618180
Published
1978-01-00
Pages
140-5
Language
English
Region
United States
NLM ID
0063733
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02618180
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2