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PMID: 24122041 Published · ppublish English Journal Article

DGIdb: mining the druggable genome.

Nature methods ·Vol. 10 ·No. 12 ·2013-12-00 ·Pages 1209-10

Griffith M, Griffith OL, Coffman AC, Weible JV, McMichael JF, Spies NC, Koval J, Das I, Callaway MB, Eldred JM, Miller CA, Subramanian J, Govindan R, Kumar RD, Bose R, Ding L, Walker JR, Larson DE, Dooling DJ, Smith SM, Ley TJ, Mardis ER, Wilson RK

Abstract

The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http://dgidb.org/.

MeSH Terms
Antineoplastic Agents/chemistry Breast Neoplasms/drug therapy,genetics Computational Biology/methods Data Mining/methods Databases, Genetic Drug Discovery/methods Drug Interactions Gene Expression Regulation/drug effects Genetic Variation Genome Genomics/methods Humans Lung Neoplasms/drug therapy,genetics Mutation Software Technology, Pharmaceutical/methods
Chemicals
Antineoplastic Agents
Authors & Affiliations
23 authors, click to expand affiliations / ORCID
Griffith Malachi ORCID
1] The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. [3].
Griffith Obi L
Coffman Adam C
Weible James V
McMichael Josh F
Spies Nicholas C
Koval James
Das Indraniel
Callaway Matthew B
Eldred James M
Miller Christopher A
Subramanian Janakiraman
Govindan Ramaswamy
Kumar Runjun D
Bose Ron
Ding Li
Walker Jason R
Larson David E
Dooling David J
Smith Scott M
Ley Timothy J
Mardis Elaine R
Wilson Richard K
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Article Info
Journal
Nature methods
Abbr.
Nat Methods
ISSN
1548-7105
DOI
10.1038/nmeth.2689
Published
2013-12-00
Epub
2013-00-13
Pages
1209-10
Language
English
Region
United States
NLM ID
101215604
PMCID
PMC3851581
Subset
IM
Grants
NCI NIH HHS · P01 CA101937 · United States
NHGRI NIH HHS · U54 HG003079 · United States
External Links
PubMed source DOI: 10.1038/nmeth.2689 PMC Full Text View journal details
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