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PMID: 2439072 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Modulation of monocyte complement synthesis by interferons.

The Biochemical journal ·Vol. 242 ·No. 3 ·1987-03-15 ·Pages 809-15

Hamilton AO, Jones L, Morrison L, Whaley K

Abstract

Recombinant Escherichia coli-derived gamma-interferon has been shown to stimulate synthesis of the second component of complement (C2), factor B and C1 inhibitor, but to inhibit synthesis of the third component (C3). alpha- and beta-interferons stimulate synthesis of factor B and C3 inhibitor, inhibit C5 synthesis but do not alter synthesis of C2. alpha- and beta-interferons act synergistically with gamma-interferon to enhance both factor B and C1-inhibitor synthesis.

MeSH Terms
Cells, Cultured Chemical Precipitation Complement Factor B/biosynthesis Complement System Proteins/biosynthesis Dose-Response Relationship, Drug Humans Interferon Type I/pharmacology Interferon-gamma/pharmacology Interferons/pharmacology Kinetics Monocytes/drug effects,metabolism
Chemicals
Interferon Type I Interferon-gamma Complement System Proteins Interferons Complement Factor B
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hamilton A O
Jones L
Morrison L
Whaley K
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27 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2420809
Published
1987-03-15
Pages
809-15
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1147782
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2420809 PMC Full Text View journal details
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