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PMID: 2446591 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The effect of DNA hypomethylating agents on the reactivation of herpes simplex virus from latently infected mouse ganglia in vitro. Brief report.

Archives of virology ·Vol. 97 ·No. 1-2 ·1987-00-00 ·Pages 137-44

Whitby AJ, Blyth WA, Hill TJ

Abstract

Effects of DNA hypomethylating agents on reactivation of herpes simplex virus from latently infected mouse ganglia in vitro were examined. L-ethionine and 5-azacytidine increased the incidence of reactivation. Dimethylsulphoxide and 5-azacytidine allowed earlier detection of virus.

MeSH Terms
Animals Azacitidine/pharmacology DNA, Viral/genetics Dimethyl Sulfoxide/pharmacology Ganglia, Sympathetic/microbiology,physiology Herpes Simplex/genetics In Vitro Techniques Methylation Mice Simplexvirus/genetics,growth & development Vero Cells Virus Replication
Chemicals
DNA, Viral Azacitidine Dimethyl Sulfoxide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Whitby A J
Department of Microbiology, University of Bristol, Medical School, U.K.
Blyth W A
Hill T J
References (20)
20 references, click to expand
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01310742
Published
1987-00-00
Pages
137-44
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01310742 View journal details
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