Evidence that neurons harbor latent herpes simplex virus.

Infection and immunity ·Vol. 9 ·No. 5 ·1974-05-00 ·Pages 946-51

Cook ML, Bastone VB, Stevens JG

Abstract

The cell type(s) harboring latent herpes simplex virus in the spinal ganglia of mice was investigated. Taken together, results from immunofluorescence, electron microscopic, autoradiographic, and in situ nucleic acid hybridization methods suggest strongly that, in mice, latent virus is maintained in neurons.

MeSH Terms

Animals Autoradiography Carrier State Culture Techniques Fluorescent Antibody Technique Ganglia, Spinal/immunology,microbiology Herpes Simplex/immunology Mice Microscopy, Electron Neurons/microbiology Nucleic Acid Hybridization Simplexvirus/isolation & purification Tritium Virus Cultivation

Chemicals

Tritium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Cook M L

Bastone V B

Stevens J G

References (13)

13 references, click to expand

The development and maintenance of myelinated tissue cultures of rat trigeminal ganglion.
Am J Anat. 1966 Sep;119(2):179-97 PMID: 5970434
Replication of varicella-zoste virus in cell culture: an ultrastructural study.
J Ultrastruct Res. 1970 Aug;32(3):334-50 PMID: 4318846
Latent herpes simplex virus in spinal ganglia of mice.
Science. 1971 Aug 27;173(3999):843-5 PMID: 4328483
Detection of Epstein-Barr viral genome in nonproductive cells.
Nat New Biol. 1971 Sep 22;233(38):103-6 PMID: 4328798
Latent herpes simplex virus from trigeminal ganglia of rabbits with recurrent eye infection.
Nat New Biol. 1972 Feb 16;235(59):216-7 PMID: 4334930
Restriction of herpes simplex virus replication by poliovirus: a selective inhibition of viral translation.
Virology. 1972 Apr;48(1):207-20 PMID: 4335934
Herpesvirus hominis: isolation from human trigeminal ganglion.
Science. 1972 Oct 20;178(4058):306-7 PMID: 4342752
Recovery of herpes-simplex virus from human trigeminal ganglions.
N Engl J Med. 1973 Mar 29;288(13):648-50 PMID: 4347057
Chronic herpes simplex virus infection. Initiation in hamsters upon implantation of infected nonpermissive glial cells.
Arch Neurol. 1973 Apr;28(4):224-30 PMID: 4347322
Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra-axonal transport of infection.
Infect Immun. 1973 Feb;7(2):272-88 PMID: 4348966
Latent herpes simplex virus in the central nervous system of rabbits and mice.
J Exp Med. 1973 Sep 1;138(3):740-4 PMID: 4353820
Human cytomegalovirus. I. Purification and characterization of viral DNA.
J Virol. 1973 Dec;12(6):1473-81 PMID: 4128379
LATENT HERPES SIMPLEX INFECTION IN MAN.
Bacteriol Rev. 1964 Dec;28:472-9 PMID: 14244725

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.9.5.946-951.1974

Published

1974-05-00

Pages

946-51

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC414911

Subset

External Links

PubMed source DOI: 10.1128/iai.9.5.946-951.1974 PMC Full Text View journal details

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Evidence that neurons harbor latent herpes simplex virus.

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