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PMID: 2451491 Published · ppublish English Journal Article

Human immunodeficiency virus replication in human brain cells. Brief report.

Archives of virology ·Vol. 99 ·No. 1-2 ·1988-00-00 ·Pages 135-41

Srinivasan A, Dorsett D, York D, Bohan C, Anand R

Abstract

Human immunodeficiency virus (HIV), the etiologic agent of AIDS, was found to infect and replicate in human brain cells. The extent of HIV replication was minimal in human brain-derived cells in comparison to T4 lymphoid cells. These results suggest that direct infection of glial/neuronal cells by HIV may contribute to the CNS dysfunction frequently observed in HIV infected individuals.

MeSH Terms
Brain/microbiology Cells, Cultured HIV/growth & development Humans In Vitro Techniques RNA-Directed DNA Polymerase/metabolism Time Factors Transfection Virus Replication
Chemicals
RNA-Directed DNA Polymerase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Srinivasan A
Retrovirus Diseases Branch, Centers for Disease Control, Atlanta, Georgia.
Dorsett D
York D
Bohan C
Anand R
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28 references, click to expand
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01311031
Published
1988-00-00
Pages
135-41
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01311031 View journal details
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