A sequence pattern common to T cell epitopes.

The EMBO journal ·Vol. 7 ·No. 1 ·1988-01-00 ·Pages 93-100

Rothbard JB, Taylor WR

Abstract

An analysis of the known cytotoxic and helper T cell epitopes has revealed similarity within their primary sequences. These similar motifs, characteristic of the known determinants, have been incorporated into predictive templates that have been used successfully to define eight helper and three cytotoxic epitopes in four different proteins. When the defined epitopes are segregated by restriction element, allele specific subpatterns emerge centering around the general pattern. The presence of similarities argues that the binding of peptide antigens to class I and class II is similar in nature. In addition, these motifs can be used to predict accurately areas within proteins capable of being recognized by individual MHC class I and class II molecules.

MeSH Terms

Amino Acid Sequence Animals Epitopes/genetics HLA Antigens/immunology Humans Information Systems Major Histocompatibility Complex Molecular Sequence Data Sequence Homology, Nucleic Acid T-Lymphocytes, Cytotoxic/immunology T-Lymphocytes, Helper-Inducer/immunology

Chemicals

Epitopes HLA Antigens

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rothbard J B

Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.

Taylor W R

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50 references, click to expand

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Article Info

Journal

The EMBO journal

Abbr.

EMBO J

ISSN

0261-4189

Published

1988-01-00

Pages

93-100

Language

English

Region

England

NLM ID

8208664

PMCID

PMC454220

Subset

External Links

PubMed source PMC Full Text View journal details

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