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PMID: 2452831 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes.

Journal of neuroimmunology ·Vol. 18 ·No. 3 ·1988-06-00 ·Pages 245-53

Lavi E, Suzumura A, Murasko DM, Murray EM, Silberberg DH, Weiss SR

Abstract

The effect of tumor necrosis factor (TNF) on expression of major histocompatibility complex (MHC) antigens was examined in mouse glial cells in vitro. TNF induced MHC class I, but not class II, antigen expression on the surface of astrocytes but not on oligodendrocytes. Glial cells do not normally express detectable amounts of MHC antigens. Thus TNF may play a role in the immunopathogenesis of neurologic diseases that involve MHC class I-restricted reactions.

MeSH Terms
Animals Astrocytes/immunology Epitopes HLA Antigens/classification,immunology Mice Neuroglia/classification,immunology Tumor Necrosis Factor-alpha/immunology
Chemicals
Epitopes HLA Antigens Tumor Necrosis Factor-alpha
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Lavi E
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104.
Suzumura A
Murasko D M
Murray E M
Silberberg D H
Weiss S R
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Article Info
Journal
Journal of neuroimmunology
Abbr.
J Neuroimmunol
ISSN
0165-5728
DOI
10.1016/0165-5728(88)90102-6
Published
1988-06-00
Pages
245-53
Language
English
Region
Netherlands
NLM ID
8109498
PMCID
PMC7120086
Subset
IM
Grants
NIAID NIH HHS · AI 17418 · United States
NINDS NIH HHS · NS 10037 · United States
NINDS NIH HHS · NS 21954 · United States
External Links
PubMed source DOI: 10.1016/0165-5728(88)90102-6 PMC Full Text View journal details
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