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PMID: 2458043 Published · ppublish English Journal Article

Bleomycin-stimulated hamster alveolar macrophages release interleukin-1.

The American journal of pathology ·Vol. 132 ·No. 3 ·1988-09-00 ·Pages 512-20

Suwabe A, Takahashi K, Yasui S, Arai S, Sendo F

Abstract

The capacity of alveolar macrophages (AM) of bleomycin-instilled hamsters to proliferate mouse thymocytes (interleukin-1 activity) and hamster fibroblasts (fibroblast proliferation (FP) activity was studied. Using bleomycin-instilled hamsters, the FP activity of AM culture supernatants was increased significantly on days 1, 5, and 10 after instillation of bleomycin. The interleukin-1 (IL-1) activity, however, was increased significantly on day 1 only as compared with saline-treated hamsters. Next, normal AM were stimulated in vitro by bleomycin. After being fractionated by chromatography, their culture supernatant showed IL-1 activity, which also indicated FP activity. These results suggest that bleomycin directly stimulates AM to release IL-1 in the fibrogenic responses.

MeSH Terms
Animals Bleomycin Cell Division Cricetinae Fibroblasts/physiology Growth Substances/metabolism In Vitro Techniques Intercellular Signaling Peptides and Proteins Interleukin-1/metabolism Lung Diseases/chemically induced,metabolism Macrophages/drug effects,metabolism,physiology Male Mesocricetus Mice Mice, Inbred C3H Peptides Pulmonary Alveoli/drug effects,metabolism,physiology
Chemicals
Growth Substances Intercellular Signaling Peptides and Proteins Interleukin-1 Peptides alveolar macrophage growth factor Bleomycin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Suwabe A
First Department of Intenral Medicine, Yamagata University School of Medicine, Japan.
Takahashi K
Yasui S
Arai S
Sendo F
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1988-09-00
Pages
512-20
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1880746
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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