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PMID: 2474256 Published · ppublish English Journal Article Review

Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma.

The American journal of pathology ·Vol. 134 ·No. 6 ·1989-06-00 ·Pages 1347-63

Sell S, Dunsford HA

Abstract

A review of the morphologic, autoradiographic, and phenotypic analysis of the cellular changes seen during induction of cancer of the liver in rats by chemical carcinogens is used to develop an alternative to the established hypothesis that chemically induced hepatocellular carcinoma arises from premalignant nodules. The authors propose that hepatocellular and ductular carcinomas arise from a pluripotent liver stem cell and that enzyme-altered foci and nodular changes are adaptive non-oncogenic responses to the toxic effects of carcinogens. It is further postulated that persistent nodules may provide an environment that nurtures development of neoplastic cells other than the altered hepatocytes that originally form the nodule. It is possible, however, that there may be more than one cellular lineage to hepatocellular cancer and that persistent nodules contain these different lineages.

MeSH Terms
Adenoma, Bile Duct/chemically induced,metabolism,pathology Animals Antibodies, Monoclonal/metabolism Bile Duct Neoplasms/chemically induced,metabolism,pathology Carcinogenicity Tests/methods Carcinogens Liver Neoplasms/chemically induced,metabolism,pathology Liver Neoplasms, Experimental/chemically induced,metabolism,pathology Neoplastic Stem Cells/pathology Phenotype Rats alpha-Fetoproteins/metabolism
Chemicals
Antibodies, Monoclonal Carcinogens alpha-Fetoproteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sell S
University of Texas Health Science Center, Department of Pathology and Laboratory Medicine, Houston 77225.
Dunsford H A
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1989-06-00
Pages
1347-63
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1879951
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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