Home LiteratureArticle Details
PMID: 2475341 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

The EMBO journal ·Vol. 8 ·No. 5 ·1989-05-00 ·Pages 1403-10

Stamenkovic I, Clark EA, Seed B

Abstract

B cells and primary carcinomas express a surface molecule, Bp50 (CDw40), absent from other hematopoietic cells and from normal epithelium, and thought to play a regulatory role in B-cell maturation and epithelial neoplasia. In this work the sequence of a cDNA clone encoding Bp50 was analyzed by a newly derived transition matrix method. Among several interesting relationships with known receptors was found an extensive homology with the nerve growth factor receptor. The mRNA is induced by gamma-interferon in both B cells and epithelial neoplasms, suggesting a role for the molecule in the development of carcinomas at sites of chronic inflammation.

MeSH Terms
Amino Acid Sequence Antigens, Differentiation, B-Lymphocyte/genetics B-Lymphocytes/immunology Base Sequence Biological Factors/pharmacology CD40 Antigens Carcinoma/genetics,immunology,metabolism Cytokines Gene Expression Regulation HLA-DR Antigens/genetics Humans Lymphocyte Activation Molecular Sequence Data Mutation Nerve Growth Factors/metabolism Receptors, Cell Surface/genetics Receptors, Nerve Growth Factor Sequence Homology, Nucleic Acid
Chemicals
Antigens, Differentiation, B-Lymphocyte Biological Factors CD40 Antigens Cytokines HLA-DR Antigens Nerve Growth Factors Receptors, Cell Surface Receptors, Nerve Growth Factor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Stamenkovic I
Department of Genetics, Harvard Medical School, Boston, MA.
Clark E A
Seed B
References (50)
50 references, click to expand
  1. Complete sequence of an HLA-dR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes.
    EMBO J. 1983;2(3):389-94 PMID: 11894954
  2. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.
    Nature. 1984 Feb 9-15;307(5951):521-7 PMID: 6320011
  3. Stable variants affecting B cell alloantigens in human lymphoid cells.
    Nature. 1978 Feb 2;271(5644):459-61 PMID: 75508
  4. Hepatitis B virus and the prevention of primary hepatocellular carcinoma.
    N Engl J Med. 1981 Mar 26;304(13):782-4 PMID: 6258074
  5. Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals.
    J Biol Chem. 1981 Jul 25;256(14):7181-6 PMID: 6265440
  6. Induction and suppression of polyclonal antibody responses by anti-Ig reagents and antigen-nonspecific helper factors: a comparison of the effects of anti-Fab, anti-IgM, and anti IgD on murine B cells.
    Immunol Rev. 1980;52:115-39 PMID: 7021394
  7. Human B-lymphocyte subpopulations. I. Differentiation of density-separated B lymphocytes.
    Clin Immunol Immunopathol. 1981 Oct;21(1):39-49 PMID: 6268340
  8. IgG induction in a human B cell line by red cell-mediated microinjection of the cytoplasm from T cell factor-stimulated B cells.
    J Immunol. 1982 Oct;129(4):1367-71 PMID: 6980930
  9. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.
    Nucleic Acids Res. 1984 Jan 25;12(2):857-72 PMID: 6694911
  10. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
    Nature. 1984 May 31-Jun 6;309(5967):418-25 PMID: 6328312
  11. B cell growth and differentiation factors.
    Immunol Rev. 1984 Apr;78:185-210 PMID: 6429034
  12. B cell growth and differentiation factors and mechanism of B cell activation.
    Immunol Rev. 1984 Apr;78:97-118 PMID: 6234224
  13. Human B lymphoma cell line producing B cell growth factor.
    J Clin Invest. 1985 Feb;75(2):732-9 PMID: 2982918
  14. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.
    Nature. 1985 Feb 28-Mar 6;313(6005):756-61 PMID: 2983222
  15. Phagocytes as carcinogens: malignant transformation produced by human neutrophils.
    Science. 1985 Mar 8;227(4691):1231-3 PMID: 3975611
  16. Minimal size plasmids containing an M13 origin for production of single-strand transducing particles.
    J Mol Appl Genet. 1984;2(6):507-17 PMID: 6099398
  17. The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.
    Cell. 1985 Apr;40(4):747-58 PMID: 2859121
  18. Sequences in the polyomavirus DNA regulatory region involved in viral DNA replication and early gene expression.
    J Virol. 1985 Jun;54(3):739-49 PMID: 2987528
  19. The LDL receptor gene: a mosaic of exons shared with different proteins.
    Science. 1985 May 17;228(4701):815-22 PMID: 2988123
  20. Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.
    Proc Natl Acad Sci U S A. 1987 Dec;84(23):8573-7 PMID: 2825196
  21. Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system.
    EMBO J. 1987 Nov;6(11):3313-6 PMID: 3501369
  22. Regulation of the synthesis of nerve growth factor.
    J Exp Biol. 1987 Sep;132:133-50 PMID: 3323396
  23. Soluble CD23 is released by B lymphocytes cycling in response to interleukin 4 and anti-Bp50 (CDw40).
    Eur J Immunol. 1988 Mar;18(3):349-53 PMID: 2965643
  24. Molecular regulation of B lymphocyte response.
    Annu Rev Immunol. 1988;6:485-512 PMID: 3289574
  25. Biochemical characteristics and partial amino acid sequence of the receptor-like human B cell and carcinoma antigen CDw40.
    J Immunol. 1989 Jan 15;142(2):562-7 PMID: 2463309
  26. Role of neurotrophic factors in development.
    Trends Genet. 1988 May;4(5):139-43 PMID: 3070864
  27. 'B-cell factors' are pleiotropic.
    Immunol Today. 1988 Feb;9(2):45-54 PMID: 3151436
  28. Molecular and cellular pathology of hepatitis B.
    Lab Invest. 1985 Jun;52(6):572-90 PMID: 3892154
  29. Reactivation by a trans-acting factor of human major histocompatibility complex Ia gene expression in interspecies hybrids between an Ia-negative human B-cell variant and an Ia-positive mouse B-cell lymphoma.
    Proc Natl Acad Sci U S A. 1985 Aug;82(15):5145-9 PMID: 3875096
  30. Purification of human B cell growth factor.
    J Immunol. 1985 Nov;135(5):3298-302 PMID: 3876383
  31. A p50 surface antigen restricted to human urinary bladder carcinomas and B lymphocytes.
    Cancer Immunol Immunother. 1985;20(1):23-8 PMID: 2998589
  32. The neu oncogene encodes an epidermal growth factor receptor-related protein.
    Nature. 1986 Jan 16-22;319(6050):226-30 PMID: 3945311
  33. Factors controlling the B-cell cycle.
    Annu Rev Immunol. 1986;4:13-36 PMID: 2939855
  34. A new method for predicting signal sequence cleavage sites.
    Nucleic Acids Res. 1986 Jun 11;14(11):4683-90 PMID: 3714490
  35. Induction of nerve growth factor receptor in Schwann cells after axotomy.
    Proc Natl Acad Sci U S A. 1986 Jun;83(11):4094-8 PMID: 3012551
  36. Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.
    Proc Natl Acad Sci U S A. 1986 Jun;83(12):4494-8 PMID: 3487090
  37. Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors.
    Nature. 1986 Sep 18-24;323(6085):226-32 PMID: 3020426
  38. Expression and structure of the human NGF receptor.
    Cell. 1986 Nov 21;47(4):545-54 PMID: 3022937
  39. Molecular structure of human lymphocyte receptor for immunoglobulin E.
    Cell. 1986 Dec 5;47(5):657-65 PMID: 2877743
  40. Augmentation of normal and malignant B cell proliferation by monoclonal antibody to the B cell-specific antigen BP50 (CDW40).
    J Immunol. 1987 Feb 1;138(3):788-94 PMID: 3492534
  41. Gene transfer and molecular cloning of the rat nerve growth factor receptor.
    Nature. 1987 Feb 12-18;325(6105):593-7 PMID: 3027580
  42. Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor.
    Nature. 1987 Mar 26-Apr 1;326(6111):353-8 PMID: 3031505
  43. Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.
    Proc Natl Acad Sci U S A. 1987 May;84(10):3365-9 PMID: 2437578
  44. An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2.
    Nature. 1987 Oct 29-Nov 4;329(6142):840-2 PMID: 3313052
  45. Growth hormone receptor and serum binding protein: purification, cloning and expression.
    Nature. 1987 Dec 10-16;330(6148):537-43 PMID: 2825030
  46. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve.
    Nature. 1987 Dec 17-23;330(6149):658-9 PMID: 3317065
  47. Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes.
    J Immunol. 1982 Dec;129(6):2773-8 PMID: 6982941
  48. Establishing homologies in protein sequences.
    Methods Enzymol. 1983;91:524-45 PMID: 6855599
  49. Analysis of the structural heterogeneity and polymorphism of human Ia antigens. Four distinct subsets of molecules are coexpressed in the Ia pool of both DR1,1 homozygous and DR3,W6 heterozygous B cell lines.
    J Exp Med. 1984 Feb 1;159(2):378-93 PMID: 6420499
  50. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1989-05-00
Pages
1403-10
Language
English
Region
England
NLM ID
8208664
PMCID
PMC400967
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2