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PMID: 6694911 Published · ppublish English Comparative Study Journal Article

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.

Nucleic acids research ·Vol. 12 ·No. 2 ·1984-01-25 ·Pages 857-72

Kozak M

Abstract

5-Noncoding sequences have been tabulated for 211 messenger RNAs from higher eukaryotic cells. The 5'-proximal AUG triplet serves as the initiator codon in 95% of the mRNAs examined. The most conspicuous conserved feature is the presence of a purine (most often A) three nucleotides upstream from the AUG initiator codon; only 6 of the mRNAs in the survey have a pyrimidine in that position. There is a predominance of C in positions -1, -2, -4 and -5, just upstream from the initiator codon. The sequence CCAGCCAUG (G) thus emerges as a consensus sequence for eukaryotic initiation sites. The extent to which the ribosome binding site in a given mRNA matches the -1 to -5 consensus sequence varies: more than half of the mRNAs in the tabulation have 3 or 4 nucleotides in common with the CCACC consensus, but only ten mRNAs conform perfectly.

MeSH Terms
Base Sequence Protein Biosynthesis Proteins/genetics RNA, Messenger/genetics Structure-Activity Relationship
Chemicals
Proteins RNA, Messenger
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kozak M
References (163)
163 references, click to expand
  1. Structural organization of the rat gene for the arginine vasopressin-neurophysin precursor.
    EMBO J. 1983;2(5):763-7 PMID: 6315416
  2. Analysis of the adult chicken beta-globin gene. Nucleotide sequence of the locus, microheterogeneity at the 5'-end of beta-globin mRNA, and aberrant nuclear RNA species.
    J Biol Chem. 1983 Mar 25;258(6):3983-90 PMID: 6833240
  3. Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone.
    Proc Natl Acad Sci U S A. 1979 Oct;76(10):4981-5 PMID: 388425
  4. Molecular cloning and characterization of cDNA sequences coding for rat relaxin.
    Nature. 1981 May 14;291(5811):127-31 PMID: 7231533
  5. Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene.
    Nature. 1982 Oct 28;299(5886):797-802 PMID: 7133118
  6. Complete sequence of an HLA-dR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes.
    EMBO J. 1983;2(3):389-94 PMID: 11894954
  7. The structure of cloned DNA complementary to catfish pancreatic somatostatin-14 messenger RNA.
    J Biol Chem. 1982 Sep 10;257(17):10372-7 PMID: 6179939
  8. Translation of insulin-related polypeptides from messenger RNAs with tandemly reiterated copies of the ribosome binding site.
    Cell. 1983 Oct;34(3):971-8 PMID: 6627393
  9. Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments.
    Nature. 1983 Apr 28;302(5911):794-800 PMID: 6188955
  10. Complete nucleotide sequence of a French bean storage protein gene: Phaseolin.
    Proc Natl Acad Sci U S A. 1983 Apr;80(7):1897-901 PMID: 16593301
  11. Structure and expression of the mouse beta 2-microglobulin gene isolated from somatic and non-expressing teratocarcinoma cells.
    EMBO J. 1983;2(7):1061-5 PMID: 6354707
  12. The uteroglobin gene region: hormonal regulation, repetitive elements and complete nucleotide sequence of the gene.
    Nucleic Acids Res. 1983 Apr 25;11(8):2257-71 PMID: 6304644
  13. Partial mRNA sequences for human A alpha, B beta, and gamma fibrinogen chains: evolutionary and functional implications.
    Proc Natl Acad Sci U S A. 1983 Jul;80(13):3953-7 PMID: 6575389
  14. Complete nucleotide sequence of the 5' noncoding region of human alpha-and beta-globin mRNA.
    Cell. 1977 Dec;12(4):1085-95 PMID: 597858
  15. Hamster preproglucagon contains the sequence of glucagon and two related peptides.
    Nature. 1983 Apr 21;302(5910):716-8 PMID: 6835407
  16. Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins.
    Science. 1983 Jul 15;221(4607):236-40 PMID: 6602382
  17. Structural analysis of sericin genes. Homologies with fibroin gene in the 5' flanking nucleotide sequences.
    J Biol Chem. 1982 Dec 25;257(24):15192-9 PMID: 6294094
  18. Characterization of a genomic clone for rat seminal vesicle secretory protein IV.
    Nucleic Acids Res. 1983 May 25;11(10):3169-86 PMID: 6304626
  19. Tissue-specific control of alpha 2u globulin gene expression: constitutive synthesis in the submaxillary gland.
    Cell. 1983 Feb;32(2):453-60 PMID: 6186396
  20. Isolation and structural organization of the human preproenkephalin gene.
    Nature. 1982 Jun 3;297(5865):431-4 PMID: 6281660
  21. DNA sequence of two closely linked human leukocyte interferon genes.
    Science. 1981 Jun 5;212(4499):1159-62 PMID: 6165082
  22. Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone.
    J Biol Chem. 1983 Oct 10;258(19):11864-70 PMID: 6137485
  23. The evolution of genes: the chicken preproinsulin gene.
    Cell. 1980 Jun;20(2):555-66 PMID: 7388949
  24. Primary structure of chicken muscle pyruvate kinase mRNA.
    Proc Natl Acad Sci U S A. 1983 Jun;80(12):3661-5 PMID: 6574503
  25. Nucleotide sequence of bovine prolactin messenger RNA. Evidence for sequence polymorphism.
    J Biol Chem. 1982 Jan 25;257(2):678-81 PMID: 6274859
  26. The 5' noncoding and flanking regions of the avian very low density apolipoprotein II and serum albumin genes. Homologies with the egg white protein genes.
    J Biol Chem. 1983 Apr 10;258(7):4556-64 PMID: 6187737
  27. Human leukocyte interferon produced by E. coli is biologically active.
    Nature. 1980 Oct 2;287(5781):411-6 PMID: 6159538
  28. Complete nucleotide sequence of a chicken H2b histone gene.
    J Biol Chem. 1982 Aug 10;257(15):8577-80 PMID: 7096326
  29. Human beta-nerve growth factor gene sequence highly homologous to that of mouse.
    Nature. 1983 Jun 30;303(5920):821-5 PMID: 6688123
  30. The primary structure of the duck alpha D-globin gene: an unusual 5' splice junction sequence.
    EMBO J. 1983;2(8):1339-43 PMID: 10872328
  31. DNA sequences, gene regulation and modular protein evolution in the Drosophila 68C glue gene cluster.
    J Mol Biol. 1983 Aug 25;168(4):765-89 PMID: 6411930
  32. Ubiquitous and gene-specific regulatory 5' sequences in a sea urchin histone DNA clone coding for histone protein variants.
    Nucleic Acids Res. 1980 Mar 11;8(5):957-77 PMID: 7443547
  33. Sea urchin histone mRNA termini are located in gene regions downstream from putative regulatory sequences.
    Nature. 1980 May 15;285(5761):147-51 PMID: 7374764
  34. Structure of the human immune interferon gene.
    Nature. 1982 Aug 26;298(5877):859-63 PMID: 6180322
  35. Evolutionary history of a multigene family: an expressed human beta-tubulin gene and three processed pseudogenes.
    Cell. 1983 Jun;33(2):477-87 PMID: 6688039
  36. Structure and expression of a cloned cDNA for human interleukin-2.
    Nature. 1983 Mar 24-30;302(5906):305-10 PMID: 6403867
  37. Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase.
    Proc Natl Acad Sci U S A. 1983 Jan;80(2):477-81 PMID: 6300847
  38. Sequence of a cDNA encoding pancreatic preprosomatostatin-22.
    Proc Natl Acad Sci U S A. 1982 Sep;79(17):5152-6 PMID: 6127673
  39. The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites.
    Cell. 1978 Dec;15(4):1125-32 PMID: 569555
  40. Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor.
    Nature. 1982 Jan 28;295(5847):299-303 PMID: 6276766
  41. Rat beta casein cDNA: sequence analysis and evolutionary comparisons.
    Nucleic Acids Res. 1982 Apr 10;10(7):2295-307 PMID: 6283475
  42. Nucleotide sequence of the rat skeletal muscle actin gene.
    Nature. 1982 Aug 26;298(5877):857-9 PMID: 6287276
  43. Structure and expression of a cloned cDNA for mouse interferon-beta.
    J Biol Chem. 1983 Aug 10;258(15):9522-9 PMID: 6688252
  44. The nucleotide sequence of rabbit embryonic globin gene beta 3.
    J Biol Chem. 1981 Nov 25;256(22):11780-6 PMID: 6271761
  45. Intragenic amplification and divergence in the mouse alpha-fetoprotein gene.
    Nature. 1981 Dec 24;294(5843):713-8 PMID: 6172714
  46. Nucleotide sequence of cloned cDNA coding for mouse epsilon casein.
    Eur J Biochem. 1982 Sep 1;126(3):569-72 PMID: 6897225
  47. Soybean leghemoglobin gene family: normal, pseudo, and truncated genes.
    Proc Natl Acad Sci U S A. 1982 Jul;79(13):4055-9 PMID: 6287463
  48. The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse.
    J Biol Chem. 1982 Jan 10;257(1):277-85 PMID: 6273429
  49. Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d.
    Science. 1983 Aug 19;221(4612):750-4 PMID: 6410508
  50. The nucleotide sequence, expression, and evolution of one member of a multigene family encoding the small subunit of ribulose-1,5-bisphosphate carboxylase in soybean.
    J Mol Appl Genet. 1982;1(6):483-98 PMID: 7153686
  51. The primary structure of rabbit beta-globin mRNA as determined from cloned DNA.
    Cell. 1977 Apr;10(4):571-85 PMID: 558827
  52. Conservation of the primary structure at the 3' end of 18S rRNA from eucaryotic cells.
    Cell. 1978 Mar;13(3):551-63 PMID: 77738
  53. Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus.
    Cell. 1983 Mar;32(3):881-90 PMID: 6299580
  54. Cloning and sequence analysis reveal structural variation among related zein genes in maize.
    Cell. 1982 Jul;29(3):1015-26 PMID: 7151164
  55. The sequence of a mouse embryonic beta-globin gene. Evolution of the gene and its signal region.
    J Biol Chem. 1982 Jan 25;257(2):1048-52 PMID: 6274852
  56. Nucleotide sequence of the coding portion of human alpha globin messenger RNA.
    J Biol Chem. 1980 Apr 10;255(7):2807-15 PMID: 6244294
  57. The complete nucleotide sequence of the major adult beta globin gene of Xenopus laevis.
    J Biol Chem. 1983 Jul 25;258(14):8521-3 PMID: 6305990
  58. An expandable gene that encodes a Drosophila glue protein is not expressed in variants lacking remote upstream sequences.
    Cell. 1982 Jul;29(3):1041-51 PMID: 6817924
  59. Cloning of cDNA encoding the pre-beta subunit of mouse thyrotropin.
    Proc Natl Acad Sci U S A. 1983 Apr;80(8):2122-6 PMID: 6572965
  60. Cloning and characterization of a mRNA-encoding rat preprosomatostatin.
    J Biol Chem. 1983 Jul 25;258(14):8781-7 PMID: 6134733
  61. Primary structures of human alpha-fetoprotein and its mRNA.
    Proc Natl Acad Sci U S A. 1983 Aug;80(15):4604-8 PMID: 6192439
  62. Rat apolipoprotein E mRNA. Cloning and sequencing of double-stranded cDNA.
    J Biol Chem. 1983 Jul 25;258(14):8993-9000 PMID: 6190813
  63. Primary structure of human pepsinogen gene.
    J Biol Chem. 1983 Apr 25;258(8):5306-11 PMID: 6300126
  64. Nucleotide sequences of H1 histone genes from Xenopus laevis. A recently diverged pair of H1 genes and an unusual H1 pseudogene.
    Nucleic Acids Res. 1983 Jun 25;11(12):4093-107 PMID: 6866767
  65. Mouse histocompatibility genes: structure and organisation of a Kd gene.
    EMBO J. 1983;2(2):245-54 PMID: 11894934
  66. Structure and sequence of the promoter area and of a 5' upstream demethylation site of the estrogen-regulated chicken vitellogenin ii gene.
    J Biol Chem. 1983 Jul 25;258(14):9024-30 PMID: 6306010
  67. Organization of the rat gamma-fibrinogen gene: alternative mRNA splice patterns produce the gamma A and gamma B (gamma ') chains of fibrinogen.
    Cell. 1982 Nov;31(1):159-66 PMID: 6897622
  68. Sequences of mouse immunoglobulin light chain genes before and after somatic changes.
    Cell. 1978 Dec;15(4):1133-44 PMID: 103630
  69. cDNA sequence of a new chicken embryonic rho-globin.
    Proc Natl Acad Sci U S A. 1981 Aug;78(8):4782-5 PMID: 6170981
  70. The nucleotide sequence of the chicken apo very low density lipoprotein II gene.
    Nucleic Acids Res. 1983 May 11;11(9):2529-40 PMID: 6856469
  71. Two structurally different genes produce the same secreted human placental lactogen hormone.
    J Biol Chem. 1983 Mar 25;258(6):3787-93 PMID: 6300056
  72. The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene.
    Cell. 1982 Dec;31(3 Pt 2):553-63 PMID: 6297773
  73. Structural analysis of the prolactin gene suggests a separate origin for its 5' end.
    Nature. 1982 Jun 17;297(5867):603-6 PMID: 6283362
  74. Leader sequences of Strongylocentrotus purpuratus histone mRNAs start at a unique heptanucleotide common to all five histone genes.
    Proc Natl Acad Sci U S A. 1980 Mar;77(3):1265-9 PMID: 6154927
  75. The nucleotide sequence of the mRNA encoding a tadpole beta-globin polypeptide of Xenopus laevis.
    J Biol Chem. 1983 Jul 10;258(13):7924-7 PMID: 6688076
  76. Cloning and sequence analysis of cDNA for ovine corticotropin-releasing factor precursor.
    Nature. 1983 Feb 10;301(5900):537-40 PMID: 6600512
  77. Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver.
    Proc Natl Acad Sci U S A. 1983 Jul;80(13):3958-62 PMID: 6306654
  78. A possible novel interaction between the 3'-end of 18 S ribosomal RNA and the 5'-leader sequence of many eukaryotic messenger RNAs.
    FEBS Lett. 1982 Oct 18;147(2):133-6 PMID: 7173385
  79. The DNA sequence of Bombyx mori fibroin gene including the 5' flanking, mRNA coding, entire intervening and fibroin protein coding regions.
    Cell. 1979 Oct;18(2):591-600 PMID: 498286
  80. Homology between the primary structure of alpha-fetoprotein, deduced from a complete cDNA sequence, and serum albumin.
    Nature. 1981 May 21;291(5812):201-5 PMID: 6164927
  81. H2A.F: an extremely variant histone H2A sequence expressed in the chicken embryo.
    Proc Natl Acad Sci U S A. 1983 May;80(10):2819-23 PMID: 6574451
  82. Human growth hormone DNA sequence and mRNA structure: possible alternative splicing.
    Nucleic Acids Res. 1981 Aug 11;9(15):3719-30 PMID: 6269091
  83. Nucleotide sequence of cloned cDNAs encoding human preproparathyroid hormone.
    Proc Natl Acad Sci U S A. 1981 Dec;78(12):7365-9 PMID: 6950381
  84. Hypoxanthine-guanine phosphoribosyltransferase genes of mouse and Chinese hamster: construction and sequence analysis of cDNA recombinants.
    Nucleic Acids Res. 1982 Nov 11;10(21):6763-75 PMID: 6294614
  85. The structure of the human histone genes: clustered but not tandemly repeated.
    Cell. 1981 Jun;24(3):661-8 PMID: 6265100
  86. Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin.
    Nature. 1979 Oct 4;281(5730):351-6 PMID: 481597
  87. AUG is the only recognisable signal sequence in the 5' non-coding regions of eukaryotic mRNA.
    Nature. 1978 Jul 6;274(5666):84-7 PMID: 662001
  88. Unusual sequence homology at the 5-ends of the developmentally regulated beta A-, beta C-, and gamma-globin genes of the goat.
    Proc Natl Acad Sci U S A. 1980 Dec;77(12):7127-31 PMID: 6164057
  89. Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line.
    Proc Natl Acad Sci U S A. 1982 Nov;79(21):6661-5 PMID: 6815656
  90. The structure and evolution of the two nonallelic rat preproinsulin genes.
    Cell. 1979 Oct;18(2):545-58 PMID: 498284
  91. A cDNA clone containing the entire coding sequence of a mouse H-2Kd histocompatibility antigen.
    Nucleic Acids Res. 1983 Mar 11;11(5):1567-77 PMID: 6298749
  92. Molecular cloning of human interleukin 2 cDNA and its expression in E. coli.
    Nucleic Acids Res. 1983 Jul 11;11(13):4307-23 PMID: 6306584
  93. Molecular cloning and nucleotide sequence of full-length of cDNA coding for porcine gastrin.
    Proc Natl Acad Sci U S A. 1982 Feb;79(4):1049-53 PMID: 6951161
  94. Primary structure of the histone H2A and H2B genes and their flanking sequences in a minor histone gene cluster of Xenopus laevis.
    FEBS Lett. 1982 Aug 2;144(2):235-41 PMID: 7117538
  95. Rat pancreatic ribonuclease messenger RNA. The nucleotide sequence of the entire mRNA and the derived amino acid sequence of the pre-enzyme.
    J Biol Chem. 1982 Dec 25;257(24):14582-5 PMID: 7174650
  96. The complete nucleotide sequence of the chick a-actin gene and its evolutionary relationship to the actin gene family.
    Nucleic Acids Res. 1982 Jul 10;10(13):3861-76 PMID: 6287424
  97. Nucleotide sequence of the human parathyroid hormone gene.
    Proc Natl Acad Sci U S A. 1983 Apr;80(8):2127-31 PMID: 6220408
  98. Human somatostatin I: sequence of the cDNA.
    Proc Natl Acad Sci U S A. 1982 Aug;79(15):4575-9 PMID: 6126875
  99. Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor.
    Nature. 1983 Jun 23-29;303(5919):722-5 PMID: 6304537
  100. Primary sequence of the 5' flanking regions of the Drosophila heat shock genes in chromosome subdivision 67B.
    Nucleic Acids Res. 1981 Apr 10;9(7):1627-42 PMID: 6262735
  101. Two similar but nonallelic rat pancreatic trypsinogens. Nucleotide sequences of the cloned cDNAs.
    J Biol Chem. 1982 Aug 25;257(16):9724-32 PMID: 6896710
  102. The human pro-opiomelanocortin gene: organization, sequence, and interspersion with repetitive DNA.
    DNA. 1982;1(2):133-43 PMID: 6299668
  103. Comparison of the nucleotide sequence of cloned human and guinea-pig pre-alpha-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene.
    Nucleic Acids Res. 1982 Jun 11;10(11):3503-15 PMID: 6285305
  104. Origin of evolutionary novelty in proteins: how a high-cysteine chorion protein has evolved.
    Proc Natl Acad Sci U S A. 1982 Jun;79(11):3551-5 PMID: 6954502
  105. The complete nucleotide sequence of the duck alpha A-globin gene.
    Gene. 1982 Dec;20(2):211-7 PMID: 7166233
  106. Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations.
    Nature. 1983 Aug 11-17;304(5926):507-13 PMID: 6308467
  107. Cloning and nucleotide sequencing of the bovine growth hormone gene.
    Nucleic Acids Res. 1982 Nov 25;10(22):7197-210 PMID: 6296767
  108. Structure of the promoter for chicken alpha 2 type I collagen gene.
    Proc Natl Acad Sci U S A. 1981 Sep;78(9):5334-8 PMID: 6946474
  109. Sequence of chicken ovalbumin mRNA.
    Nature. 1978 Jun 29;273(5665):723-8 PMID: 661981
  110. The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region.
    Nature. 1980 Aug 14;286(5774):684-7 PMID: 6774259
  111. Construction of chimeric plasmids containing histone H5 cDNA from hen erythrocyte. DNA sequence of a fragment derived from the 5' region of H5 mRNA.
    Nucleic Acids Res. 1982 Mar 25;10(6):2093-108 PMID: 6176944
  112. Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes.
    Cell. 1980 Oct;21(3):627-38 PMID: 7438203
  113. Exons encode functional and structural units of chicken lysozyme.
    Proc Natl Acad Sci U S A. 1980 Oct;77(10):5759-63 PMID: 6934509
  114. Analysis of sequence microheterogeneity among zein messenger RNAs.
    J Biol Chem. 1982 Sep 10;257(17):9976-83 PMID: 6286660
  115. Unusual structure of the chicken embryonic alpha-globin gene, pi'.
    Proc Natl Acad Sci U S A. 1983 Mar;80(5):1392-6 PMID: 6572397
  116. Nucleotide sequence of cloned cDNA of human apolipoprotein A-I.
    Nucleic Acids Res. 1983 Jun 11;11(11):3703-15 PMID: 6304641
  117. Anglerfish islet pre-proglucagon II. Nucleotide and corresponding amino acid sequence of the cDNA.
    J Biol Chem. 1983 Mar 10;258(5):3280-4 PMID: 6338015
  118. The sequences of an expressed rat alpha-tubulin gene and a pseudogene with an inserted repetitive element.
    Nature. 1982 Nov 25;300(5890):330-5 PMID: 6927856
  119. DNA sequence of a major human leukocyte interferon gene.
    Proc Natl Acad Sci U S A. 1981 Sep;78(9):5435-9 PMID: 6170983
  120. Structure and expression of cloned murine IFN-alpha genes.
    Nucleic Acids Res. 1983 Feb 11;11(3):555-73 PMID: 6188104
  121. Rat pancreatic kallikrein mRNA: nucleotide sequence and amino acid sequence of the encoded preproenzyme.
    Proc Natl Acad Sci U S A. 1982 Dec;79(23):7263-7 PMID: 6961406
  122. Rat prostatic steroid binding protein: DNA sequence and transcript maps of the two C3 genes.
    EMBO J. 1983;2(5):769-74 PMID: 6685625
  123. Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27.
    Nature. 1983 Aug 11-17;304(5926):547-9 PMID: 6571696
  124. A previously unrecognized influenza B virus glycoprotein from a bicistronic mRNA that also encodes the viral neuraminidase.
    Proc Natl Acad Sci U S A. 1983 Aug;80(16):4879-83 PMID: 6308656
  125. Nucleotide sequence of bovine parathyroid hormone messenger RNA.
    Mol Cell Endocrinol. 1982 Nov-Dec;28(3):411-24 PMID: 6185374
  126. Nucleotide sequence of the mRNA encoding the pre-alpha-subunit of mouse thyrotropin.
    Proc Natl Acad Sci U S A. 1981 Sep;78(9):5329-33 PMID: 6272299
  127. Mouse liver and salivary gland alpha-amylase mRNAs differ only in 5' non-translated sequences.
    Nature. 1981 Feb 19;289(5799):643-6 PMID: 6162108
  128. Functional significance and evolutionary development of the 5'-terminal regions of immunoglobulin variable-region genes.
    Cell. 1982 Jun;29(2):681-9 PMID: 6288267
  129. Molecular cloning of Phaseolus vulgaris lectin mRNA and use of cDNA as a probe to estimate lectin transcript levels in various tissues.
    Nucleic Acids Res. 1982 Dec 11;10(23):7819-28 PMID: 6897567
  130. Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli.
    Nature. 1983 Jan 20;301(5897):214-21 PMID: 6337343
  131. The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha.
    Nature. 1980 Oct 2;287(5781):401-8 PMID: 6159536
  132. An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH.
    Cell. 1980 Apr;19(4):981-92 PMID: 6769593
  133. Structure-function relationship of 5' non-coding sequence of rabbit alpha- and beta-globin mRNA.
    Nature. 1977 May 19;267(5608):279-81 PMID: 865623
  134. Complete nucleotide sequence of the 5' noncoding region of rabbit beta-globin mRNA.
    Cell. 1977 Apr;10(4):549-58 PMID: 67896
  135. Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish.
    Nature. 1980 Nov 13;288(5787):137-41 PMID: 6107860
  136. Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase.
    Proc Natl Acad Sci U S A. 1983 Jan;80(2):472-6 PMID: 6188151
  137. Messenger RNA sequence and primary structure of preproinsulin in a primitive vertebrate, the Atlantic hagfish.
    J Biol Chem. 1981 Jul 25;256(14):7595-602 PMID: 6265453
  138. Human interferon gamma is encoded by a single class of mRNA.
    Nucleic Acids Res. 1982 Jun 25;10(12):3605-15 PMID: 6180381
  139. Sequence and structure conservation in yolk proteins and their genes.
    J Mol Biol. 1983 Mar 15;164(4):481-92 PMID: 6405043
  140. Isolation and analysis of genomic DNA clones encoding the third component of mouse complement.
    Proc Natl Acad Sci U S A. 1982 Dec;79(23):7077-81 PMID: 6985486
  141. Nucleotide sequence analysis of the cloned salmon preproinsulin cDNA.
    Gene. 1982 Dec;20(3):367-76 PMID: 6897724
  142. Molecular cloning of DNA complementary to bovine growth hormone mRNA.
    J Biol Chem. 1980 Aug 25;255(16):7521-4 PMID: 6893197
  143. Multiple mRNAs are generated from the chicken lysozyme gene.
    Cell. 1981 Sep;25(3):743-52 PMID: 7285117
  144. Characterization of the structural gene and putative 5'-regulatory sequences for human proopiomelanocortin.
    Nature. 1982 May 27;297(5864):335-9 PMID: 6927850
  145. Correct transcription of a cloned mouse immunoglobulin gene in vivo.
    Proc Natl Acad Sci U S A. 1983 Jan;80(2):417-21 PMID: 6300842
  146. Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs.
    Nature. 1981 Feb 19;289(5799):650-5 PMID: 7464932
  147. Isolation and characterization of cDNA clones for human skeletal muscle alpha actin.
    Nucleic Acids Res. 1983 Jun 11;11(11):3503-16 PMID: 6190133
  148. Nucleotide sequence of cloned cDNA coding for honeybee prepromelittin.
    Eur J Biochem. 1983 Sep 1;135(1):123-6 PMID: 6309516
  149. Nucleotide sequences of cloned cDNA fragments specific for six Xenopus laevis ribosomal proteins.
    Gene. 1982 Mar;17(3):311-6 PMID: 7049839
  150. The complete nucleotide sequence of the chicken ovotransferrin mRNA.
    Eur J Biochem. 1982 Feb;122(2):291-5 PMID: 7060577
  151. Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin.
    Proc Natl Acad Sci U S A. 1983 Jul;80(14):4311-4 PMID: 6192430
  152. The nucleotide sequence of rat liver fatty acid binding protein mRNA.
    J Biol Chem. 1983 Mar 10;258(5):3356-63 PMID: 6298233
  153. Nucleotide sequence of cloned cDNA of human c-myc oncogene.
    Nature. 1983 Jun 23-29;303(5919):725-8 PMID: 6304538
  154. Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA.
    Nature. 1982 Feb 25;295(5851):663-6 PMID: 7057924
  155. Comparison of the nucleic acid sequence of anglerfish and mammalian insulin mRNA's from cloned cDNA's.
    Science. 1980 Dec 19;210(4476):1360-3 PMID: 7001633
  156. Structure of mouse metallothionein-I gene and its mRNA.
    Nature. 1981 Jul 16;292(5820):267-9 PMID: 7254320
  157. Genomic organization, DNA sequence, and expression of chicken embryonic histone genes.
    J Biol Chem. 1983 Jul 25;258(14):9005-16 PMID: 6190814
  158. Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem.
    Proc Natl Acad Sci U S A. 1982 Jan;79(2):345-9 PMID: 7043459
  159. The rat casein multigene family. I. Fine structure of the gamma-casein gene.
    J Biol Chem. 1983 Sep 10;258(17):10794-804 PMID: 6309815
  160. Mouse whey acidic protein is a novel member of the family of 'four-disulfide core' proteins.
    Nucleic Acids Res. 1982 Apr 24;10(8):2677-84 PMID: 6896234
  161. Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides.
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  162. The seal myoglobin gene: an unusually long globin gene.
    Nature. 1983 Feb 24;301(5902):732-4 PMID: 6828156
  163. Mutants of yeast initiating translation of iso-1-cytochrome c within a region spanning 37 nucleotides.
    Cell. 1980 May;20(1):215-22 PMID: 6248233
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/12.2.857
Published
1984-01-25
Pages
857-72
Language
English
Region
England
NLM ID
0411011
PMCID
PMC318541
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/12.2.857 PMC Full Text View journal details
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