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PMID: 24800935 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Brains in metamorphosis: reprogramming cell identity within the central nervous system.

Current opinion in neurobiology ·Vol. 27 ·2014-08-00 ·Pages 208-14

Arlotta P, Berninger B

Abstract

During embryonic development, uncommitted pluripotent cells undergo progressive epigenetic changes that lock them into a final differentiated state. Can mammalian cells change identity within the living organism? Direct lineage reprogramming of cells has attracted attention as a means to achieve organ regeneration. However, it is unclear whether cells in the CNS are endowed with the plasticity to reprogram. Neurons in particular are considered among the most immutable cell types, able to retain their class-specific traits for the lifespan of the organism. Here we focus on two experimental paradigms, glia-to-neuron and neuron-to-neuron conversion, to consider how lineage reprogramming has challenged the notion of CNS immutability, paving the way for the application of reprogramming strategies to reshape neurons and circuits in vivo.

MeSH Terms
Animals Cellular Reprogramming/physiology Central Nervous System/cytology,physiology Humans Induced Pluripotent Stem Cells Metamorphosis, Biological/physiology Neurons/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Arlotta Paola
Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave, Cambridge, USA. Electronic address: [email protected].
Berninger Benedikt
Research group "Adult Neurogenesis and Cellular Reprogramming", Institute of Physiological Chemistry, and Focus Program Translational Neuroscience, University Medical Center, Johannes Gutenberg University Mainz, Hanns-Dieter-Hüsch-Weg 19, Mainz, Germany; Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Schillerstrasse 46, D-80336 Munich, Germany. Electronic address: [email protected].
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Article Info
Journal
Current opinion in neurobiology
Abbr.
Curr Opin Neurobiol
ISSN
1873-6882
DOI
10.1016/j.conb.2014.04.007
Email
[email protected]
[email protected]
Published
2014-08-00
Epub
2014-00-04
Pages
208-14
Language
English
Region
England
NLM ID
9111376
PMCID
PMC4122594
Subset
IM
Grants
NIMH NIH HHS · R01 MH101268 · United States
NINDS NIH HHS · R01 NS062849 · United States
NINDS NIH HHS · R01 NS078164 · United States
External Links
PubMed source DOI: 10.1016/j.conb.2014.04.007 PMC Full Text View journal details
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