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PMID: 2504480 Published · ppublish English Journal Article Review

Rocky Mountain spotted fever: a disease in need of microbiological concern.

Clinical microbiology reviews ·Vol. 2 ·No. 3 ·1989-07-00 ·Pages 227-40

Walker DH

Abstract

Rocky Mountain spotted fever, a life-threatening tick-transmitted infection, is the most prevalent rickettsiosis in the United States. This zoonosis is firmly entrenched in the tick host, which maintains the rickettsiae in nature by transovarian transmission. Although the incidence of disease fluctuates in various regions and nationwide, the problems of a deceptively difficult clinical diagnosis and little microbiologic diagnostic effort persist. Many empiric antibiotic regimens lack antirickettsial activity. There is neither an effective vaccine nor a generally available assay that is diagnostic during the early stages of illness, when treatment is most effective. Microbiology laboratories that offer only the archaic retrospective Weil-Felix serologic tests should review the needs of their patients. Research microbiologists who tackle these challenging organisms have an array of questions to address regarding rickettsial surface composition, structure-function analysis, and pathogenic and immune mechanisms, as well as laboratory diagnosis.

MeSH Terms
Animals Ecology Humans Rickettsia rickettsii/physiology Rocky Mountain Spotted Fever/microbiology,prevention & control Ticks/microbiology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Walker D H
Department of Pathology, University of Texas Medical Branch, Galveston 77550.
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Article Info
Journal
Clinical microbiology reviews
Abbr.
Clin Microbiol Rev
ISSN
0893-8512
DOI
10.1128/CMR.2.3.227
Published
1989-07-00
Pages
227-40
Language
English
Region
United States
NLM ID
8807282
PMCID
PMC358117
Subset
IM
External Links
PubMed source DOI: 10.1128/CMR.2.3.227 PMC Full Text View journal details
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