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PMID: 25066614 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Central role of soluble adenylyl cyclase and cAMP in sperm physiology.

Biochimica et biophysica acta ·Vol. 1842 ·No. 12 Pt B ·2014-12-00 ·Pages 2610-20

Buffone MG, Wertheimer EV, Visconti PE, Krapf D

Abstract

Cyclic adenosine 3',5'-monophosphate (cAMP), the first second messenger to be described, plays a central role in cell signaling in a wide variety of cell types. Over the last decades, a wide body of literature addressed the different roles of cAMP in cell physiology, mainly in response to neurotransmitters and hormones. cAMP is synthesized by a wide variety of adenylyl cyclases that can generally be grouped in two types: transmembrane adenylyl cyclase and soluble adenylyl cyclases. In particular, several aspects of sperm physiology are regulated by cAMP produced by a single atypical adenylyl cyclase (Adcy10, aka sAC, SACY). The signature that identifies sAC among other ACs, is their direct stimulation by bicarbonate. The essential nature of cAMP in sperm function has been demonstrated using gain of function as well as loss of function approaches. This review unifies state of the art knowledge of the role of cAMP and those enzymes involved in cAMP signaling pathways required for the acquisition of fertilizing capacity of mammalian sperm. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease.

Keywords
Soluble adenylyl cyclase Sperm capacitation Transmembrane adenylyl cyclase cAMP
MeSH Terms
Adenylyl Cyclases/metabolism,physiology Cyclic AMP/metabolism,physiology Cyclic AMP-Dependent Protein Kinases/metabolism Humans Hydrolysis Male Signal Transduction Spermatozoa/enzymology,physiology
Chemicals
Cyclic AMP Cyclic AMP-Dependent Protein Kinases ADCY10 protein, human Adenylyl Cyclases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Buffone Mariano G
Instituto de Biología y Medicina Experimental, National Research Council of Argentina (CONICET), Buenos Aires, Argentina.
Wertheimer Eva V
Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Visconti Pablo E
Department of Veterinary and Animal Sciences, ISB, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: [email protected].
Krapf Dario
Instituto de Biología Molecular y Celular de Rosario (CONICET), UNR, Rosario, Argentina; Facultad de Ciencias Bioquímicas y Farmacéuticas, UNR, Rosario, Argentina.
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbadis.2014.07.013
Email
[email protected]
Published
2014-12-00
Epub
2014-00-24
Pages
2610-20
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC4262597
Subset
IM
Grants
NICHD NIH HHS · R01 HD044044 · United States
NICHD NIH HHS · R01 HD038082 · United States
FIC NIH HHS · R01 TW008662 · United States
FIC NIH HHS · R01-TW008662 · United States
NICHD NIH HHS · R01 HD44044 · United States
External Links
PubMed source DOI: 10.1016/j.bbadis.2014.07.013 PMC Full Text
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