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PMID: 25082288 Published · ppublish English Journal Article Review

Semaphorins and plexins as therapeutic targets.

Nature reviews. Drug discovery ·Vol. 13 ·No. 8 ·2014-08-00 ·Pages 603-21

Worzfeld T, Offermanns S

Abstract

Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions and are involved in cell-cell communication. Most of the effects of semaphorins are mediated by plexins. Work over the past decade has revealed crucial functions of the semaphorin-plexin system in mammalian physiology. It has also become clear that semaphorins and plexins have important roles in many pathophysiological processes, including cancer, immunological diseases and bone disorders, and that they represent novel targets for drugs to prevent or treat various diseases. This Review summarizes the functions of the mammalian semaphorin-plexin system as well as its role in diseases and discusses emerging strategies to pharmacologically target semaphorin-plexin signalling.

MeSH Terms
Animals Bone Diseases/physiopathology Bone and Bones/physiology Cell Adhesion Molecules/physiology Cell Communication/drug effects,physiology Central Nervous System/physiology Humans Neoplasms/drug therapy,physiopathology Nerve Regeneration/physiology Nerve Tissue Proteins/physiology Receptors, Cell Surface/drug effects,physiology Semaphorins/physiology Signal Transduction/drug effects,physiology
Chemicals
Cell Adhesion Molecules Nerve Tissue Proteins Receptors, Cell Surface Semaphorins plexin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Worzfeld Thomas
1] Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Ludwigstr. 43, 61231 Bad Nauheim, Germany. [2] Institute of Pharmacology, University of Marburg, Karl-von-Frisch-Str. 1, 35043 Marburg, Germany.
Offermanns Stefan
1] Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Ludwigstr. 43, 61231 Bad Nauheim, Germany. [2] Medical Faculty, J.W. Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
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Article Info
Journal
Nature reviews. Drug discovery
Abbr.
Nat Rev Drug Discov
ISSN
1474-1784
DOI
10.1038/nrd4337
Published
2014-08-00
Pages
603-21
Language
English
Region
England
NLM ID
101124171
Subset
IM
Databases
ClinicalTrials.gov
NCT01313065, NCT01764737
External Links
PubMed source DOI: 10.1038/nrd4337 View journal details
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