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PMID: 25091736 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Senescent stroma promotes prostate cancer progression: the role of miR-210.

Molecular oncology ·Vol. 8 ·No. 8 ·2014-12-00 ·Pages 1729-46

Taddei ML, Cavallini L, Comito G, Giannoni E, Folini M, Marini A, Gandellini P, Morandi A, Pintus G, Raspollini MR, Zaffaroni N, Chiarugi P

Abstract

We focused our interest on senescent human-derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy-rich compounds to support cancer cell growth. Hypoxic senescent fibroblasts additionally increase: i) the recruitment of monocytes and their M2-macrophage polarization, ii) the recruitment of bone marrow-derived endothelial precursor cells, facilitating their vasculogenic ability and iii) capillary morphogenesis, proliferation and invasion of human mature endothelial cells. In addition, we highlight that overexpression of the hypoxia-induced miR-210 in young fibroblasts increases their senescence-associated features and converts them into cancer associated fibroblast (CAF)-like cells, able to promote cancer cells EMT, to support angiogenesis and to recruit endothelial precursor cells and monocytes/macrophages.

Keywords
Prostate cancer Senescence Tumor microenvironment miR-210
MeSH Terms
Cell Line Cell Line, Tumor Cells, Cultured Disease Progression Humans Immunohistochemistry Male MicroRNAs/genetics,metabolism Prostatic Neoplasms/genetics,metabolism,pathology
Chemicals
MIRN210 microRNA, human MicroRNAs
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Taddei Maria Letizia
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy. Electronic address: [email protected].
Cavallini Lorenzo
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.
Comito Giuseppina
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.
Giannoni Elisa
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.
Folini Marco
Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Amadeo 42, 20133 Milan, Italy.
Marini Alberto
Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B 07100 Sassari, Italy.
Gandellini Paolo
Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Amadeo 42, 20133 Milan, Italy.
Morandi Andrea
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.
Pintus Gianfranco
Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B 07100 Sassari, Italy.
Raspollini Maria Rosaria
Histology and Molecular Diagnostic, University Hospital Careggi, Viale G.B. Morgagni 85, 50134 Florence, Italy.
Zaffaroni Nadia
Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Amadeo 42, 20133 Milan, Italy.
Chiarugi Paola
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy; Center for Research, Transfer and High Education 'Study at Molecular and Clinical Level of Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development on Novel Therapies', Italy.
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Article Info
Journal
Molecular oncology
Abbr.
Mol Oncol
ISSN
1878-0261
DOI
10.1016/j.molonc.2014.07.009
Email
[email protected]
Published
2014-12-00
Epub
2014-00-21
Pages
1729-46
Language
English
Region
United States
NLM ID
101308230
PMCID
PMC5528604
Subset
IM
External Links
PubMed source DOI: 10.1016/j.molonc.2014.07.009 PMC Full Text View journal details
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