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PMID: 2530159 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Antigen-specific inhibition of IL-2 and IL-3 production in contact sensitivity to TNP.

Immunology ·Vol. 68 ·No. 2 ·1989-10-00 ·Pages 185-9

Marcinkiewicz J, Chain B

Abstract

The production of IL-2 and IL-3 by T cells from mice which had been contact sensitized to TNP and/or tolerized by intravenous injections of TNBS was assayed. Contact sensitization rapidly primes T cells, so that they respond to in vitro restimulation with haptenated syngeneic cells by producing IL-2 and IL-3. This production is strongly inhibited, in an antigen-specific manner, in tolerized mice. At least part of this inhibition can be attributed to the action of suppressor T cells that act by preventing the activation of lymphokine production in vitro. Lymphokine production thus closely parallels the in vivo delayed-type hypersensitivity (DTH) reaction in this system.

MeSH Terms
Animals Antigens/immunology Dermatitis, Contact/immunology Immune Tolerance Interleukin-2/biosynthesis Interleukin-3/biosynthesis Male Mice Mice, Inbred CBA Nitrobenzenes/immunology T-Lymphocytes/metabolism T-Lymphocytes, Regulatory/immunology Trinitrobenzenes/immunology Trinitrobenzenesulfonic Acid/immunology
Chemicals
Antigens Interleukin-2 Interleukin-3 Nitrobenzenes Trinitrobenzenes Trinitrobenzenesulfonic Acid
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Marcinkiewicz J
Department of Immunology, N. Copernicus Medical Academy, Cracow, Poland.
Chain B
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16 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1989-10-00
Pages
185-9
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1385414
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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