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PMID: 25352330 Published · ppublish English Journal Article Review

Purinergic signalling and immune cells.

Purinergic signalling ·Vol. 10 ·No. 4 ·2014-12-00 ·Pages 529-64

Burnstock G, Boeynaems JM

Abstract

This review article provides a historical perspective on the role of purinergic signalling in the regulation of various subsets of immune cells from early discoveries to current understanding. It is now recognised that adenosine 5'-triphosphate (ATP) and other nucleotides are released from cells following stress or injury. They can act on virtually all subsets of immune cells through a spectrum of P2X ligand-gated ion channels and G protein-coupled P2Y receptors. Furthermore, ATP is rapidly degraded into adenosine by ectonucleotidases such as CD39 and CD73, and adenosine exerts additional regulatory effects through its own receptors. The resulting effect ranges from stimulation to tolerance depending on the amount and time courses of nucleotides released, and the balance between ATP and adenosine. This review identifies the various receptors involved in the different subsets of immune cells and their effects on the function of these cells.

MeSH Terms
Animals Humans Immune System/immunology,metabolism Purines/immunology Receptors, Purinergic/metabolism Signal Transduction/physiology
Chemicals
Purines Receptors, Purinergic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Burnstock Geoffrey
Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK, [email protected].
Boeynaems Jean-Marie
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Article Info
Journal
Purinergic signalling
Abbr.
Purinergic Signal
ISSN
1573-9546
DOI
10.1007/s11302-014-9427-2
Email
[email protected]
Published
2014-12-00
Epub
2014-00-29
Pages
529-64
Language
English
Region
Netherlands
NLM ID
101250499
PMCID
PMC4272370
Subset
IM
External Links
PubMed source DOI: 10.1007/s11302-014-9427-2 PMC Full Text View journal details
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