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PMID: 18463789 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Purinergic regulation of neutrophil chemotaxis.

Cellular and molecular life sciences : CMLS ·Vol. 65 ·No. 16 ·2008-08-00 ·Pages 2528-40

Junger WG

Abstract

Chemotaxis allows polymorphonuclear neutrophils (PMN) to rapidly reach infected and inflamed sites. However, excessive influx of PMN damages host tissues. Better knowledge of the mechanisms that control PMN chemotaxis may lead to improved treatments of inflammatory diseases. Recent findings suggest that ATP and adenosine are involved in PMN chemotaxis. Therefore, these purinergic signaling processes may be suitable targets for novel therapeutic approaches to ameliorate host tissue damage.

MeSH Terms
Adenosine Triphosphate/metabolism Animals Chemotaxis, Leukocyte Humans Models, Biological Neutrophils/cytology Purines/metabolism Receptors, Purinergic/metabolism
Chemicals
Purines Receptors, Purinergic Adenosine Triphosphate
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Junger W G
Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, East Stoneman 8M 10C, Boston, Massachusetts 02215, USA. [email protected]
References (152)
152 references, click to expand
  1. Neutrophil granule constituents and their release in health and disease.
    Hematol Oncol Clin North Am. 1988 Mar;2(1):101-34 PMID: 2831184
  2. Ectonucleotidases in the nervous system.
    Novartis Found Symp. 2006;276:113-28; discussion 128-30, 233-7, 275-81 PMID: 16805426
  3. Surface expression of HSP72 by LPS-stimulated neutrophils facilitates gammadeltaT cell-mediated killing.
    Eur J Immunol. 2006 Mar;36(3):712-21 PMID: 16482515
  4. ATP-conducting maxi-anion channel: a new player in stress-sensory transduction.
    Jpn J Physiol. 2004 Feb;54(1):7-14 PMID: 15040843
  5. ATP as a signaling molecule: the exocrine focus.
    News Physiol Sci. 2003 Feb;18:12-7 PMID: 12531926
  6. Epidemiology of trauma deaths: a reassessment.
    J Trauma. 1995 Feb;38(2):185-93 PMID: 7869433
  7. Epidemiology of trauma deaths.
    Am J Surg. 1980 Jul;140(1):144-50 PMID: 7396078
  8. Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance.
    Crit Care. 2003 Aug;7(4):291-307 PMID: 12930553
  9. Molecular events during leukocyte diapedesis.
    FEBS J. 2006 Oct;273(19):4399-407 PMID: 16965541
  10. Death in the operating room: an analysis of a multi-center experience.
    J Trauma. 1994 Sep;37(3):426-32 PMID: 8083904
  11. Immunomodulatory impact of the A2A adenosine receptor on the profile of chemokines produced by neutrophils.
    FASEB J. 2006 Jan;20(1):187-9 PMID: 16280366
  12. Orientation of chemotactic cells and growth cones: models and mechanisms.
    J Cell Sci. 1999 Sep;112 ( Pt 17):2867-74 PMID: 10444381
  13. A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells.
    Am J Physiol Cell Physiol. 2007 Oct;293(4):C1420-5 PMID: 17699635
  14. Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house?
    Eur J Immunol. 2004 Nov;34(11):2955-63 PMID: 15376193
  15. Hypertonic stress regulates T-cell function by the opposing actions of extracellular adenosine triphosphate and adenosine.
    Shock. 2007 Mar;27(3):242-50 PMID: 17304104
  16. The A3 adenosine receptor: an enigmatic player in cell biology.
    Pharmacol Ther. 2008 Jan;117(1):123-40 PMID: 18029023
  17. Characterization of a large conductance non-selective anion channel in B lymphocytes.
    Cell Signal. 1989;1(1):31-44 PMID: 2484331
  18. Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation.
    J Biol Chem. 2003 Feb 14;278(7):4590-6 PMID: 12464620
  19. Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands.
    Curr Opin Hematol. 2002 Jan;9(1):30-5 PMID: 11753075
  20. Swelling-activated, cystic fibrosis transmembrane conductance regulator-augmented ATP release and Cl- conductances in murine C127 cells.
    J Physiol. 2000 Feb 15;523 Pt 1:1-11 PMID: 10673540
  21. Osmotic regulation of cell function and possible clinical applications.
    Shock. 2004 May;21(5):391-400 PMID: 15087814
  22. Beneficial suicide: why neutrophils die to make NETs.
    Nat Rev Microbiol. 2007 Aug;5(8):577-82 PMID: 17632569
  23. Redistribution of membrane 5'-nucleotidase in rabbit peritoneal polymorphonuclear leucocytes during phagocytosis.
    FEBS Lett. 1983 Jun 13;156(2):329-34 PMID: 6303859
  24. Rapid release of endothelin and ATP from isolated aortic endothelial cells exposed to increased flow.
    Biochem Biophys Res Commun. 1990 Jul 31;170(2):649-56 PMID: 2200403
  25. Bench-to-bedside review: acute respiratory distress syndrome - how neutrophils migrate into the lung.
    Crit Care. 2004 Dec;8(6):453-61 PMID: 15566616
  26. Inhibiting adenosine deaminase modulates the systemic inflammatory response syndrome in endotoxemia and sepsis.
    Am J Physiol Regul Integr Comp Physiol. 2002 May;282(5):R1324-32 PMID: 11959672
  27. Pattern formation by local self-activation and lateral inhibition.
    Bioessays. 2000 Aug;22(8):753-60 PMID: 10918306
  28. Increased flow-induced ATP release from isolated vascular endothelial cells but not smooth muscle cells.
    Br J Pharmacol. 1991 May;103(1):1203-5 PMID: 1652343
  29. Kinetics and characteristics of bovine neutrophil alkaline phosphatase during acute Escherichia coli mastitis.
    J Dairy Sci. 1992 Jul;75(7):1826-34 PMID: 1500578
  30. The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism.
    Front Biosci. 2008 Jan 01;13:2588-603 PMID: 17981736
  31. Redistribution of ecto-5'-nucleotidase during phagocytosis by guinea pig polymorphonuclear leukocytes.
    J Leukoc Biol. 1984 Oct;36(4):463-75 PMID: 6090556
  32. Neutrophil disorders and their management.
    J Clin Pathol. 2001 Jan;54(1):7-19 PMID: 11271792
  33. Effect of adenosine A2A receptor activation in murine models of respiratory disorders.
    Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L1036-43 PMID: 16339780
  34. Mechanical stress induces release of ATP from Ehrlich ascites tumor cells.
    Biochim Biophys Acta. 1999 Jan 12;1416(1-2):271-84 PMID: 9889382
  35. The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively.
    J Clin Invest. 1990 Apr;85(4):1150-7 PMID: 2156895
  36. How superoxide production by neutrophil leukocytes kills microbes.
    Novartis Found Symp. 2006;279:92-8; discussion 98-100, 216-9 PMID: 17278388
  37. Early neutrophil sequestration after injury: a pathogenic mechanism for multiple organ failure.
    J Trauma. 1995 Sep;39(3):411-7 PMID: 7473901
  38. Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils.
    Biophys J. 2002 Jan;82(1 Pt 1):50-63 PMID: 11751295
  39. Electron microscopic cytochemical localization of nucleoside phosphatases in normal and chronic granulocytic leukaemic human neutrophils.
    Histochem J. 1981 Jan;13(1):73-84 PMID: 6112213
  40. Neutrophil apoptosis pathways and their modifications in inflammation.
    Immunol Rev. 2003 Jun;193:101-10 PMID: 12752675
  41. Biology of hematopoietic stem cells and progenitors: implications for clinical application.
    Annu Rev Immunol. 2003;21:759-806 PMID: 12615892
  42. Effect of adenosine triphosphate-magnesium chloride administration in shock.
    Surgery. 1974 Feb;75(2):220-7 PMID: 4812045
  43. Theophylline induces neutrophil apoptosis through adenosine A2A receptor antagonism.
    J Leukoc Biol. 2000 Apr;67(4):529-35 PMID: 10770286
  44. Protective effect of an adenosine kinase inhibitor in septic shock.
    J Immunol. 1994 Jun 15;152(12):5853-9 PMID: 8207212
  45. Suppression of TNF-alpha production in human mononuclear cells by an adenosine kinase inhibitor.
    J Leukoc Biol. 2000 Jul;68(1):97-103 PMID: 10914495
  46. Mechanical strain-induced Ca(2+) waves are propagated via ATP release and purinergic receptor activation.
    Am J Physiol Cell Physiol. 2000 Aug;279(2):C295-307 PMID: 10912995
  47. Adenosine triphosphate-magnesium chloride: relevance for intensive care.
    Intensive Care Med. 2003 Jan;29(1):10-8 PMID: 12528016
  48. The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance.
    Purinergic Signal. 2006 Jun;2(2):409-30 PMID: 18404480
  49. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy.
    Pharmacol Rev. 2006 Sep;58(3):281-341 PMID: 16968944
  50. Adenosine receptors as promising therapeutic targets for drug development in chronic airway inflammation.
    Curr Drug Targets. 2006 Jun;7(6):699-706 PMID: 16787172
  51. Colony stimulating factors and hemopoiesis.
    Ann Acad Med Singap. 1988 Apr;17(2):166-70 PMID: 3044253
  52. Hypertonic saline solutions for treatment of intracranial hypertension.
    Curr Opin Anaesthesiol. 2007 Oct;20(5):414-26 PMID: 17873594
  53. Involvement of Rho-kinase and tyrosine kinase in hypotonic stress-induced ATP release in bovine aortic endothelial cells.
    J Physiol. 2001 May 1;532(Pt 3):759-69 PMID: 11313444
  54. Rhythms in human bone marrow and blood cells.
    Chronobiol Int. 2002 Jan;19(1):101-27 PMID: 11962670
  55. Purines and neutrophil leukocytes.
    Gen Pharmacol. 1997 Mar;28(3):345-50 PMID: 9068971
  56. Receptors for purines and pyrimidines.
    Pharmacol Rev. 1998 Sep;50(3):413-92 PMID: 9755289
  57. Pharmacology and therapeutic applications of A3 receptor subtype.
    Curr Top Med Chem. 2003;3(4):463-9 PMID: 12570762
  58. Atypical neutrophil alkaline phosphatase associated with impaired neutrophil functions.
    Clin Chim Acta. 1998 Sep 14;277(1):77-89 PMID: 9776047
  59. How human neutrophils kill and degrade microbes: an integrated view.
    Immunol Rev. 2007 Oct;219:88-102 PMID: 17850484
  60. Hypertonic saline enhances neutrophil elastase release through activation of P2 and A3 receptors.
    Am J Physiol Cell Physiol. 2006 Apr;290(4):C1051-9 PMID: 16282197
  61. Studies on the oxygen radical mechanism involved in the small intestinal reperfusion damage.
    Acta Physiol Scand. 1985 Aug;124(4):581-9 PMID: 2996301
  62. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils.
    Cell. 2003 Jul 25;114(2):201-14 PMID: 12887922
  63. Feedback signaling controls leading-edge formation during chemotaxis.
    Curr Opin Genet Dev. 2006 Aug;16(4):339-47 PMID: 16806895
  64. Role of adenosine in immunomodulation: review of the literature.
    Crit Care Med. 2004 Jan;32(1):273-7 PMID: 14707591
  65. Platelet-neutrophil-interactions: linking hemostasis and inflammation.
    Blood Rev. 2007 Mar;21(2):99-111 PMID: 16987572
  66. Cellular motility driven by assembly and disassembly of actin filaments.
    Cell. 2003 Feb 21;112(4):453-65 PMID: 12600310
  67. Adenosine activates A2 receptors to inhibit neutrophil adhesion and injury to isolated cardiac myocytes.
    J Immunol. 1995 Sep 1;155(5):2579-86 PMID: 7650388
  68. Adenosine kinase inhibitor GP515 attenuates hepatic leukocyte adhesion after hemorrhagic hypotension.
    Am J Physiol. 1997 Dec;273(6):G1297-303 PMID: 9435554
  69. The anti-inflammatory effect of A3 adenosine receptor agonists: a novel targeted therapy for rheumatoid arthritis.
    Expert Opin Investig Drugs. 2007 Oct;16(10):1601-13 PMID: 17922624
  70. Assessment of alkaline phosphatase on the surface membrane of neutrophils by immunofluorescence.
    Am J Hematol. 1999 Jan;60(1):12-8 PMID: 9883800
  71. Inhibition of thrombin-induced signaling by resveratrol and quercetin: effects on adenosine nucleotide metabolism in endothelial cells and platelet-neutrophil interactions.
    Thromb Res. 2004;114(3):185-94 PMID: 15342215
  72. Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation.
    Semin Thromb Hemost. 2005 Apr;31(2):217-33 PMID: 15852225
  73. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.
    Immunity. 2005 Mar;22(3):285-94 PMID: 15780986
  74. The direction of membrane lipid flow in locomoting polymorphonuclear leukocytes.
    Science. 1990 Mar 9;247(4947):1229-33 PMID: 2315695
  75. On the association between transmitter secretion and the release of adenine nucleotides from mammalian motor nerve terminals.
    J Physiol. 1975 May;247(1):145-62 PMID: 166162
  76. Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome.
    Expert Opin Emerg Drugs. 2007 Sep;12(3):461-77 PMID: 17874973
  77. A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors.
    J Leukoc Biol. 2004 Jul;76(1):245-53 PMID: 15107462
  78. Osmotic cell swelling-induced ATP release mediates the activation of extracellular signal-regulated protein kinase (Erk)-1/2 but not the activation of osmo-sensitive anion channels.
    Biochem J. 1999 Nov 1;343 Pt 3:579-86 PMID: 10527936
  79. Acetylcholine and ATP are coreleased from the electromotor nerve terminals of Narcine brasiliensis by an exocytotic mechanism.
    Proc Natl Acad Sci U S A. 1990 Jan;87(2):553-7 PMID: 2137245
  80. Volume-dependent ATP-conductive large-conductance anion channel as a pathway for swelling-induced ATP release.
    J Gen Physiol. 2001 Sep;118(3):251-66 PMID: 11524456
  81. The diadenosine polyphosphates Ap3A and Ap4A and adenosine triphosphate interact with granulocyte-macrophage colony-stimulating factor to delay neutrophil apoptosis: implications for neutrophil: platelet interactions during inflammation.
    Blood. 1996 Apr 15;87(8):3442-9 PMID: 8605363
  82. Adenosine, an endogenous distress signal, modulates tissue damage and repair.
    Cell Death Differ. 2007 Jul;14(7):1315-23 PMID: 17396131
  83. Cellular release of and response to ATP as key determinants of the set-point of signal transduction pathways.
    J Biol Chem. 2000 Apr 21;275(16):11735-9 PMID: 10766795
  84. Synovial fluid from patients with rheumatoid arthritis inhibits neutrophil apoptosis: role of adenosine and proinflammatory cytokines.
    Rheumatology (Oxford). 2002 Nov;41(11):1249-60 PMID: 12421997
  85. Adenosine kinase inhibitor GP515 improves experimental colitis in mice.
    J Pharmacol Exp Ther. 2001 Jan;296(1):99-105 PMID: 11123368
  86. Targeting leukocyte integrins in human diseases.
    J Leukoc Biol. 2005 Feb;77(2):129-40 PMID: 15548573
  87. Immunodeficiency diseases caused by defects in phagocytes.
    N Engl J Med. 2000 Dec 7;343(23):1703-14 PMID: 11106721
  88. Cl- channels in intact human T lymphocytes.
    J Membr Biol. 1992 Jan;125(2):171-83 PMID: 1372657
  89. Synaptic corelease of ATP and GABA in cultured spinal neurons.
    Nat Neurosci. 1999 Mar;2(3):241-5 PMID: 10195216
  90. The effect of systemic hypoxia on interstitial and blood adenosine, AMP, ADP and ATP in dog skeletal muscle.
    J Physiol. 2001 Oct 15;536(Pt 2):593-603 PMID: 11600692
  91. Immune cell migration in inflammation: present and future therapeutic targets.
    Nat Immunol. 2005 Dec;6(12):1182-90 PMID: 16369557
  92. Neutrophil-mediated tissue injury and its modulation.
    Intensive Care Med. 1995 Mar;21(3):277-85 PMID: 7790621
  93. Adenosine promotes neutrophil chemotaxis.
    J Exp Med. 1988 Mar 1;167(3):1186-94 PMID: 2832507
  94. Macula densa cell signaling involves ATP release through a maxi anion channel.
    Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4322-7 PMID: 12655045
  95. Ca2+-dependent myosin II activation is required for uropod retraction during neutrophil migration.
    J Cell Sci. 2000 Apr;113 ( Pt 7):1287-98 PMID: 10704379
  96. Extracellular metabolism of ATP and other nucleotides.
    Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):299-309 PMID: 11111825
  97. Cloning of a stretch-inhibitable nonselective cation channel.
    J Biol Chem. 1999 Mar 5;274(10):6330-5 PMID: 10037722
  98. Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation.
    Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4654-9 PMID: 10758162
  99. A3 adenosine receptor as a target for cancer therapy.
    Anticancer Drugs. 2002 Jun;13(5):437-43 PMID: 12045454
  100. P2U agonists induce chemotaxis and actin polymerization in human neutrophils and differentiated HL60 cells.
    J Biol Chem. 1996 Jun 28;271(26):15597-601 PMID: 8663069
  101. Adenosine 5'-triphosphate: a P2-purinergic agonist in the myocardium.
    Physiol Rev. 2001 Apr;81(2):767-806 PMID: 11274344
  102. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors.
    Science. 2006 Dec 15;314(5806):1792-5 PMID: 17170310
  103. Chemotaxis: signalling the way forward.
    Nat Rev Mol Cell Biol. 2004 Aug;5(8):626-34 PMID: 15366706
  104. CD39/NTPDase-1 activity and expression in normal leukocytes.
    Thromb Res. 2007;121(3):309-17 PMID: 17555802
  105. Adenosine receptors as therapeutic targets.
    Nat Rev Drug Discov. 2006 Mar;5(3):247-64 PMID: 16518376
  106. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function.
    Circ Res. 2006 Nov 10;99(10):1100-8 PMID: 17038639
  107. Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3'-kinase.
    Biochem Pharmacol. 2004 Jan 1;67(1):129-34 PMID: 14667935
  108. Effects of extracellular nucleotides in the thyroid: P2Y2 receptor-mediated ERK1/2 activation and c-Fos induction in PC Cl3 cells.
    Cell Signal. 2005 Jun;17(6):739-49 PMID: 15722198
  109. Renal cell-to-cell communication via extracellular ATP.
    Physiology (Bethesda). 2005 Apr;20:86-90 PMID: 15772296
  110. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation.
    Pharmacol Ther. 2006 Nov;112(2):358-404 PMID: 16784779
  111. Infections in patients with inherited defects in phagocytic function.
    Clin Microbiol Rev. 2003 Oct;16(4):597-621 PMID: 14557288
  112. P2Y(2) nucleotide receptor signaling in human monocytic cells: activation, desensitization and coupling to mitogen-activated protein kinases.
    J Cell Physiol. 2001 May;187(2):196-208 PMID: 11267999
  113. Signalling via ATP in the nervous system.
    Trends Neurosci. 1994 Oct;17(10):420-6 PMID: 7530880
  114. Adenosine A2a receptor activation delays apoptosis in human neutrophils.
    J Immunol. 1997 Mar 15;158(6):2926-31 PMID: 9058831
  115. Inhibition of neutrophil chemotaxis by purinoceptor agonists.
    Arch Int Pharmacodyn Ther. 1992 May-Jun;317:93-106 PMID: 1456845
  116. A3 adenosine receptor activation inhibits cell proliferation via phosphatidylinositol 3-kinase/Akt-dependent inhibition of the extracellular signal-regulated kinase 1/2 phosphorylation in A375 human melanoma cells.
    J Biol Chem. 2005 May 20;280(20):19516-26 PMID: 15774470
  117. P2 receptors meet the immune system.
    Trends Pharmacol Sci. 2001 Jan;22(1):5-7 PMID: 11261415
  118. When is a stem cell really a stem cell?
    Bone Marrow Transplant. 2003 Aug;32 Suppl 1:S7-11 PMID: 12931232
  119. Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.
    Blood. 2000 Sep 1;96(5):1646-54 PMID: 10961859
  120. Hematopoietic stem cells: old and new.
    Biomed Pharmacother. 2001 Mar;55(2):75-8 PMID: 11293816
  121. Hypertonic saline: a clinical review.
    Neurosurg Rev. 2007 Oct;30(4):277-89; discussion 289-90 PMID: 17574484
  122. Distribution of P2Y receptor subtypes on haematopoietic cells.
    Br J Pharmacol. 1998 Mar;123(5):789-94 PMID: 9535005
  123. Elevated expression of A3 adenosine receptors in human colorectal cancer is reflected in peripheral blood cells.
    Clin Cancer Res. 2004 Sep 1;10(17):5895-901 PMID: 15355922
  124. Attenuation of ischemic liver injury by augmentation of endogenous adenosine.
    Transplantation. 1997 Jan 27;63(2):217-23 PMID: 9020320
  125. Magnesium-adenosine triphosphate in the treatment of shock, ischemia, and sepsis.
    Crit Care Med. 1992 Feb;20(2):263-75 PMID: 1737460
  126. Colloids versus crystalloids for fluid resuscitation in critically ill patients.
    Cochrane Database Syst Rev. 2007 Oct 17;(4):CD000567 PMID: 17943746
  127. A large, multiple-conductance chloride channel in normal human T lymphocytes.
    Pflugers Arch. 1990 Jun;416(4):413-21 PMID: 1697943
  128. Hypertonicity regulates the function of human neutrophils by modulating chemoattractant receptor signaling and activating mitogen-activated protein kinase p38.
    J Clin Invest. 1998 Jun 15;101(12):2768-79 PMID: 9637711
  129. The anti-inflammatory potential of adenosine in ischemia-reperfusion injury: established and putative beneficial actions of a retaliatory metabolite.
    Shock. 1997 Nov;8(5):313-20 PMID: 9361340
  130. Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP.
    Am J Physiol Cell Physiol. 2001 Aug;281(2):C524-31 PMID: 11443051
  131. Attenuation of ecto-5'-nucleotidase activity and adenosine release in activated human polymorphonuclear leukocytes.
    Circ Res. 1993 Sep;73(3):524-33 PMID: 8348695
  132. Moving forward: mechanisms of chemoattractant gradient sensing.
    Physiology (Bethesda). 2004 Oct;19:300-8 PMID: 15381759
  133. Neutrophil alkaline phosphatase activity increase in bacterial infections is not associated with a general increase in secretory vesicle membrane components.
    Infect Immun. 1995 Mar;63(3):911-6 PMID: 7868263
  134. Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells.
    Biophys J. 2004 Dec;87(6):3764-74 PMID: 15465874
  135. Cell-to-cell spread of calcium signals mediated by ATP receptors in mast cells.
    Nature. 1992 Sep 17;359(6392):241-4 PMID: 1388246
  136. Chediak-Higashi syndrome: a clinical and molecular view of a rare lysosomal storage disorder.
    Curr Mol Med. 2002 Aug;2(5):469-77 PMID: 12125812
  137. Cell-cell interactions: leukocyte-endothelial interactions.
    Curr Opin Hematol. 2003 Mar;10(2):150-8 PMID: 12579042
  138. A novel human Cl(-) channel family related to Drosophila flightless locus.
    J Biol Chem. 2004 May 21;279(21):22461-8 PMID: 15010458
  139. Extracellular ATP as a signaling molecule for epithelial cells.
    Biochim Biophys Acta. 2003 Sep 2;1615(1-2):7-32 PMID: 12948585
  140. Overexpression of A3 adenosine receptor in peripheral blood mononuclear cells in rheumatoid arthritis: involvement of nuclear factor-kappaB in mediating receptor level.
    J Rheumatol. 2007 Jan;34(1):20-6 PMID: 17216675
  141. Preferential usage of the bone-type leader sequence for the transcripts of liver/bone/kidney-type alkaline phosphatase gene in neutrophilic granulocytes.
    Blood. 1994 Feb 15;83(4):1093-101 PMID: 7509208
  142. Nucleotide receptors: an emerging family of regulatory molecules in blood cells.
    Blood. 2001 Feb 1;97(3):587-600 PMID: 11157473
  143. Autocrine regulation of volume-sensitive anion channels in airway epithelial cells by adenosine.
    J Biol Chem. 1999 Apr 23;274(17):11701-7 PMID: 10206984
  144. Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes.
    Thromb Haemost. 1999 Nov;82(5):1538-44 PMID: 10595651
  145. Navigating signaling networks: chemotaxis in Dictyostelium discoideum.
    Curr Opin Genet Dev. 2006 Aug;16(4):333-8 PMID: 16782326
  146. Targeting systemic inflammation: novel therapies for the treatment of chronic obstructive pulmonary disease.
    Expert Opin Ther Targets. 2007 Oct;11(10):1273-86 PMID: 17907958
  147. Local and global changes in cytosolic free calcium in neutrophils during chemotaxis and phagocytosis.
    Cell Calcium. 1990 Feb-Mar;11(2-3):181-90 PMID: 2354498
  148. Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells.
    Am J Physiol. 1996 Feb;270(2 Pt 1):C522-9 PMID: 8779915
  149. Induction of apoptosis in HL-60 human promyelocytic leukemia cells by adenosine A(3) receptor agonists.
    Biochem Biophys Res Commun. 1996 Feb 27;219(3):904-10 PMID: 8645277
  150. Effect of shear stress on the release of soluble ecto-enzymes ATPase and 5'-nucleotidase along with endogenous ATP from vascular endothelial cells.
    Br J Pharmacol. 2000 Mar;129(5):921-6 PMID: 10696091
  151. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.
    Nat Cell Biol. 2002 Jul;4(7):509-13 PMID: 12080346
  152. Novel medications for asthma: a look at the future.
    Expert Opin Investig Drugs. 2007 Jun;16(6):889-97 PMID: 17501700
Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-682X
DOI
10.1007/s00018-008-8095-1
Email
[email protected]
Published
2008-08-00
Pages
2528-40
Language
English
Region
Switzerland
NLM ID
9705402
PMCID
PMC4214070
Subset
IM
Grants
NIGMS NIH HHS · R01 GM060475 · United States
NIGMS NIH HHS · R01 GM051477 · United States
NIGMS NIH HHS · R29 GM051477 · United States
NIGMS NIH HHS · GM-60475 · United States
NIAID NIH HHS · R01 AI080582 · United States
NIAID NIH HHS · R01 AI072287 · United States
NIGMS NIH HHS · R01 GM-51477 · United States
External Links
PubMed source DOI: 10.1007/s00018-008-8095-1 PMC Full Text View journal details
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