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PMID: 2535749 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Amplification of mouse mammary tumor virus genomes in non-mammary tumor cells.

Journal of virology ·Vol. 63 ·No. 1 ·1989-01-00 ·Pages 456-9

Racevskis J, Beyer H

Abstract

Extra proviral copies of mouse mammary tumor virus (MMTV) are known to be present in the genomes of certain T-cell lymphomas of mice. Analysis of additional non-mammary tumor cell types known to express MMTV transcripts and antigens revealed the presence of extra acquired MMTV proviruses in a pituitary tumor cell line, a macrophage line, and Leydig testicular tumor cells. The nature of the amplified MMTV proviruses in these various tumor cell types differed with regard to copy number and presence of alterations in the long terminal repeat region.

MeSH Terms
Animals Base Sequence Cell Line DNA Probes DNA, Neoplasm/genetics Gene Amplification Genes, Viral Leydig Cell Tumor Macrophages Male Mammary Tumor Virus, Mouse/genetics Mice Molecular Sequence Data Pituitary Neoplasms Proviruses/genetics Repetitive Sequences, Nucleic Acid Testicular Neoplasms Tumor Cells, Cultured
Chemicals
DNA Probes DNA, Neoplasm
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Racevskis J
Department of Oncology, Montefiore, Cancer Center, Bronx, New York.
Beyer H
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24 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.63.1.456-459.1989
Published
1989-01-00
Pages
456-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC247707
Subset
IM
Grants
NCI NIH HHS · CA-43864 · United States
External Links
PubMed source DOI: 10.1128/JVI.63.1.456-459.1989 PMC Full Text View journal details
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