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PMID: 2536150 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

tRNA derived insertion element in histone gene repeating unit of Drosophila melanogaster.

Nucleic acids research ·Vol. 17 ·No. 1 ·1989-01-11 ·Pages 225-38

Matsuo Y, Yamazaki T

Abstract

Analysis of 41 histone homologous clones from an isogenic gene library of Drosophila melanogaster showed that non-histone fragments interrupt the histone repetitive clusters at several sites. Long (L) and short (S) forms of the repeating units are distinguished by the insertion of 240 bp into the spacer between H1 and H3 of the L units; Each form appears to be clustered with its own kind. The complete DNA sequence of the histone 5.0 kb repeating unit was determined. Five histone genes (H1, H2A, H2B, H3, H4) were identified in a repeating unit and several sequence blocks common to the five histone genes were found in the 5'- and 3'-regions. The insertion sequence of 240 bp was found to be similar to the Alu family, an element derived from tRNA.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA Transposable Elements Drosophila melanogaster/genetics Genes Histones/genetics Molecular Sequence Data Nucleic Acid Conformation RNA, Transfer/genetics Repetitive Sequences, Nucleic Acid Restriction Mapping
Chemicals
DNA Transposable Elements Histones RNA, Transfer
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Matsuo Y
Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan.
Yamazaki T
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/17.1.225
Published
1989-01-11
Pages
225-38
Language
English
Region
England
NLM ID
0411011
PMCID
PMC331547
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/17.1.225 PMC Full Text View journal details
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