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PMID: 25428358 Published · ppublish English Journal Article Research Support, N.I.H., Intramural

NCBI viral genomes resource.

Nucleic acids research ·Vol. 43 ·No. Database issue ·2015-01-00 ·Pages D571-7

Brister JR, Ako-Adjei D, Bao Y, Blinkova O

Abstract

Recent technological innovations have ignited an explosion in virus genome sequencing that promises to fundamentally alter our understanding of viral biology and profoundly impact public health policy. Yet, any potential benefits from the billowing cloud of next generation sequence data hinge upon well implemented reference resources that facilitate the identification of sequences, aid in the assembly of sequence reads and provide reference annotation sources. The NCBI Viral Genomes Resource is a reference resource designed to bring order to this sequence shockwave and improve usability of viral sequence data. The resource can be accessed at http://www.ncbi.nlm.nih.gov/genome/viruses/ and catalogs all publicly available virus genome sequences and curates reference genome sequences. As the number of genome sequences has grown, so too have the difficulties in annotating and maintaining reference sequences. The rapid expansion of the viral sequence universe has forced a recalibration of the data model to better provide extant sequence representation and enhanced reference sequence products to serve the needs of the various viral communities. This, in turn, has placed increased emphasis on leveraging the knowledge of individual scientific communities to identify important viral sequences and develop well annotated reference virus genome sets.

MeSH Terms
Databases, Nucleic Acid Genome, Viral High-Throughput Nucleotide Sequencing Internet Molecular Sequence Annotation Software Viruses/classification
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Brister J Rodney
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA [email protected].
Ako-Adjei Danso
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Bao Yiming
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Blinkova Olga
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
DOI
10.1093/nar/gku1207
Email
[email protected]
Published
2015-01-00
Epub
2014-00-26
Pages
D571-7
Language
English
Region
England
NLM ID
0411011
PMCID
PMC4383986
Subset
IM
Grants
Intramural NIH HHS · United States
External Links
PubMed source DOI: 10.1093/nar/gku1207 PMC Full Text View journal details
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