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PMID: 2543286 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Activities of daptomycin and teicoplanin against Staphylococcus haemolyticus and Staphylococcus epidermidis, including evaluation of susceptibility testing recommendations.

Antimicrobial agents and chemotherapy ·Vol. 33 ·No. 4 ·1989-04-00 ·Pages 585-8

Low DE, McGeer A, Poon R

Abstract

The in vitro activities of daptomycin, teicoplanin, and three other antimicrobial agents were determined against 105 strains of Staphylococcus haemolyticus and 92 strains of Staphylococcus epidermidis. The MICs for 90% of strains tested (MIC90s) of fusidic acid and rifampin were less than or equal to 0.25 microgram/ml. The MIC90s of daptomycin and vancomycin were less than or equal to 4 micrograms/ml. Teicoplanin had a comparable MIC90 of less than or equal to 4 micrograms/ml for isolates of S. epidermidis. However, MIC90s were 8 and 16 micrograms/ml for oxacillin-susceptible and oxacillin-resistant S. haemolyticus, respectively. Disk diffusion tests were evaluated for daptomycin and teicoplanin. Disks with 30 micrograms of teicoplanin performed satisfactorily when S. epidermidis was tested, but when S. haemolyticus was tested, there was a very major error rate of 10% and a minor error rate of 38%.

MeSH Terms
Anti-Bacterial Agents/pharmacology Daptomycin Drug Resistance, Microbial Evaluation Studies as Topic Glycopeptides/pharmacology Microbial Sensitivity Tests Oxacillin/pharmacology Peptides/pharmacology Staphylococcus/drug effects Staphylococcus epidermidis/drug effects Teicoplanin Vancomycin/pharmacology
Chemicals
Anti-Bacterial Agents Glycopeptides Peptides Teicoplanin Vancomycin Daptomycin Oxacillin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Low D E
Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada.
McGeer A
Poon R
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28 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.33.4.585
Published
1989-04-00
Pages
585-8
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC172486
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.33.4.585 PMC Full Text View journal details
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