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PMID: 6221692 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

In vitro activity of teichomycin and vancomycin alone and in combination with rifampin.

Antimicrobial agents and chemotherapy ·Vol. 23 ·No. 3 ·1983-03-00 ·Pages 402-6

Varaldo PE, Debbia E, Schito GC

Abstract

The antibacterial activity of teichomycin, a glycopeptide antibiotic similar to vancomycin, has been evaluated in vitro and compared with that of vancomycin. Test strains included 130 staphylococci and 132 streptococci, with representatives of the major currently recognized species or groups, and lesser numbers of clostridia, propionibacteria, and group JK bacteria. Teichomycin was found to be more active than vancomycin. Its minimum inhibitory concentration (MIC) was two- to fourfold lower than that of vancomycin with staphylococci and anaerobic bacteria, and two- to eightfold lower with streptococci. No significant differences were observed with group JK bacteria. For most strains tested, minimum bactericidal concentrations (MBCs) of both teichomycin and vancomycin either equalled or exceeded by twofold the respective MICs. Higher MBC-to-MIC ratios were obtained for enterococci and pneumococci with both antibiotics. Both teichomycin and vancomycin showed similar in vitro interactions with rifampin in combination tests. Neither antagonism nor (with very few exceptions) synergism occurred.

MeSH Terms
Anti-Bacterial Agents/pharmacology Bacteria/drug effects Drug Interactions Microbial Sensitivity Tests Rifampin/pharmacology Teicoplanin Vancomycin/pharmacology
Chemicals
Anti-Bacterial Agents Teicoplanin Vancomycin Rifampin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Varaldo P E
Debbia E
Schito G C
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22 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.23.3.402
Published
1983-03-00
Pages
402-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC184660
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.23.3.402 PMC Full Text View journal details
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