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PMID: 2557315 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Coexpression of platelet-derived growth factor (PDGF) A-chain and PDGF receptor genes in human gastric carcinomas.

Japanese journal of cancer research : Gann ·Vol. 80 ·No. 9 ·1989-09-00 ·Pages 813-7

Tsuda T, Yoshida K, Tsujino T, Nakayama H, Kajiyama G, Tahara E

Abstract

In this study we examined the expression of platelet-derived growth factor (PDGF) A-chain and PDGF receptor genes in seven human gastric carcinoma cell lines and 15 gastric carcinoma tissues. Expression of mRNA for PDGF A-chain was found in all gastric cell lines and all gastric carcinoma tissues. Two of the seven gastric carcinoma cell lines expressed PDGF receptor mRNA. Out of the 15 gastric carcinoma tissues, eight showed enhanced expression of PDGF receptor mRNA and all of them demonstrated prominent fibrous stroma. Moreover, the incidence of enhanced expression of PDGF receptor mRNA was higher in scirrhous carcinoma than in well differentiated adenocarcinoma. These results strongly suggest that PDGF produced by tumor cells acts as a paracrine growth factor for production of fibrous stroma in gastric carcinomas.

MeSH Terms
Adult Aged Blotting, Northern Female Gene Expression Humans Male Middle Aged Platelet-Derived Growth Factor/genetics RNA, Messenger/analysis Receptors, Cell Surface/genetics Receptors, Platelet-Derived Growth Factor Stomach Neoplasms/analysis,pathology
Chemicals
Platelet-Derived Growth Factor RNA, Messenger Receptors, Cell Surface Receptors, Platelet-Derived Growth Factor
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Tsuda T
First Department of Pathology, Hiroshima University School of Medicine.
Yoshida K
Tsujino T
Nakayama H
Kajiyama G
Tahara E
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Article Info
Journal
Japanese journal of cancer research : Gann
Abbr.
Jpn J Cancer Res
ISSN
0910-5050
DOI
10.1111/j.1349-7006.1989.tb01719.x
Published
1989-09-00
Pages
813-7
Language
English
Region
Japan
NLM ID
8509412
PMCID
PMC5917854
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1349-7006.1989.tb01719.x PMC Full Text
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