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PMID: 2567264 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human.

Genetics ·Vol. 122 ·No. 1 ·1989-05-00 ·Pages 153-61

Buchberg AM, Brownell E, Nagata S, Jenkins NA, Copeland NG

Abstract

Interspecific backcross animals from a cross between C57BL/6J and Mus spretus mice were used to generate a comprehensive linkage map of mouse chromosome 11. The relative map positions of genes previously assigned to mouse chromosome 11 by somatic cell hybrid or genetic backcross analysis were determined (Erbb, Rel, 11-3, Csfgm, Trp53-1, Evi-2, Erba, Erbb-2, Csfg, Myhs, Cola-1, Myla, Hox-2 and Pkca). We also analyzed genes that we suspected would map to chromosome 11 by virtue of their location in human chromosomes and the known linkage homologies that exist between murine chromosome 11 and human chromosomes (Mpo, Ngfr, Pdgfr and Fms). Two of the latter genes, Mpo and Ngfr, mapped to mouse chromosome 11. Both genes also mapped to human chromosome 17, extending the degree of linkage conservation observed between human chromosome 17 and mouse chromosome 11. Pdgfr and Fms, which are closely linked to II-3 and Csfgm in humans on chromosome 5, mapped to mouse chromosome 18 rather than mouse chromosome 11, thereby defining yet another conserved linkage group between human and mouse chromosomes. The mouse chromosome 11 linkage map generated in these studies substantially extends the framework for identifying homologous genes in the mouse that are involved in human disease, for elucidating the genes responsible for several mouse mutations, and for gaining insights into chromosome evolution and genome organization.

MeSH Terms
Animals Blotting, Southern Chromosome Mapping Crosses, Genetic DNA/isolation & purification Genetic Linkage Humans Mice Mice, Inbred C57BL Polymorphism, Restriction Fragment Length
Chemicals
DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Buchberg A M
Mammalian Genetics Laboratory, NCI-Frederick Cancer Research Facility, Maryland 21701.
Brownell E
Nagata S
Jenkins N A
Copeland N G
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/122.1.153
Published
1989-05-00
Pages
153-61
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1203679
Subset
IM
Grants
NCI NIH HHS · N01-CO-74101 · United States
External Links
PubMed source DOI: 10.1093/genetics/122.1.153 PMC Full Text View journal details
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