Bicuculline and picrotoxin block gamma-aminobutyric acid-gated Cl- conductance by different mechanisms.

Experientia ·Vol. 41 ·No. 1 ·1985-01-15 ·Pages 70-1

Akaike N, Hattori K, Oomura Y, Carpenter DO

Abstract

Using isolated, internally perfused bullfrog dorsal root ganglion cells we have studied the dose-response curves for gamma-aminobutyric acid (GABA) in the presence of internally or externally applied GABA antagonists. With external application of antagonists the inhibition of the GABA current by bicuculline was competitive and that by picrotoxin was noncompetitive. Picrotoxin but not bicuculline blocked when internally perfused.

MeSH Terms

Animals Bicuculline/pharmacology Binding, Competitive Chlorides/metabolism Electric Conductivity Ganglia, Spinal/drug effects,physiology Ion Channels/drug effects,physiology Picrotoxin/pharmacology Rana catesbeiana gamma-Aminobutyric Acid/pharmacology

Chemicals

Chlorides Ion Channels Picrotoxin gamma-Aminobutyric Acid Bicuculline

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Akaike N

Hattori K

Oomura Y

Carpenter D O

References (12)

12 references, click to expand

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Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

10.1007/BF02005880

Published

1985-01-15

Pages

70-1

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

PubMed source DOI: 10.1007/BF02005880

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Bicuculline and picrotoxin block gamma-aminobutyric acid-gated Cl- conductance by different mechanisms.

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