Home LiteratureArticle Details
PMID: 6260951 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Acetylcholine receptor kinetics.

The Journal of membrane biology ·Vol. 58 ·No. 3 ·1981-02-28 ·Pages 161-74

Adams PR

Abstract

暂无摘要

MeSH Terms
Acetylcholine/physiology Animals Electric Conductivity Ion Channels/physiology Kinetics Motor Endplate/physiology Neuromuscular Junction/physiology Receptors, Cholinergic/physiology
Chemicals
Ion Channels Receptors, Cholinergic Acetylcholine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Adams P R
References (114)
114 references, click to expand
  1. A covalently bound photoisomerizable agonist: comparison with reversibly bound agonists at Electrophorus electroplaques.
    J Gen Physiol. 1980 Feb;75(2):207-32 PMID: 6246192
  2. Voltage jump analysis of procaine action at frog end-plate.
    J Physiol. 1977 Jun;268(2):291-318 PMID: 301570
  3. Molecular forms of acetylcholine receptor. Effects of calcium ions and a sulfhydryl reagent on the occurrence of oligomers.
    Biochemistry. 1977 Oct 4;16(20):4513-20 PMID: 410440
  4. Decamethonium in depolarized muscle and the effects of tubocurarine.
    J Physiol. 1970 Sep;210(2):345-61 PMID: 5501266
  5. Relaxation measurements on the acetylcholine receptor.
    Proc Natl Acad Sci U S A. 1975 Sep;72(9):3496-500 PMID: 1059136
  6. Voltage fluctuations at the frog sartorius motor endplate produced by a covalently attached activator.
    J Membr Biol. 1979 Dec 14;51(2):145-59 PMID: 316828
  7. Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells.
    J Physiol. 1979 Oct;295:139-70 PMID: 42780
  8. Disulfide bond cross-linked dimer in acetylcholine receptor from Torpedo californica.
    Biochem Biophys Res Commun. 1977 Dec 7;79(3):692-9 PMID: 597297
  9. Noise analysis of drug induced voltage clamp currents in denervated frog muscle fibres.
    J Physiol. 1976 Jul;258(3):705-29 PMID: 1086359
  10. Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction.
    J Physiol. 1973 Dec;235(3):655-91 PMID: 4543940
  11. Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist.
    Nature. 1980 Jul 3;286(5768):71-3 PMID: 6248795
  12. Ligand-induced changes in membrane-bound acetylcholine receptor observed by ethidium fluorescence. 2. Stopped-flow studies with agonists and antagonists.
    Biochemistry. 1979 May 15;18(10):1891-901 PMID: 435453
  13. Effects of procaine on ionic conductances of end-plate membranes.
    J Pharmacol Exp Ther. 1971 Feb;176(2):423-33 PMID: 5568785
  14. Reconstitution of a functional acetylcholine regulator under defined conditions.
    FEBS Lett. 1979 Sep 1;105(1):181-7 PMID: 488341
  15. Effects of membrane potential, temperature and neostigmine on the conductance change caused by a quantum or acetylcholine at the toad neuromuscular junction.
    J Physiol. 1975 Jan;244(2):385-407 PMID: 806678
  16. Immunochemical similarities between subunits of acetylcholine receptors from Torpedo, Electrophorus, and mammalian muscle.
    Biochemistry. 1979 Oct 16;18(21):4470-80 PMID: 497151
  17. Fast kinetic studies on the interaction of cholinergic agonists with the membrane-bound acetylcholine receptor from Torpedo marmorata as revealed by quinacrine fluorescence.
    Eur J Biochem. 1977 Oct 17;80(1):225-42 PMID: 923575
  18. Drug-receptor interaction at the frog neuromuscular junction.
    Prog Brain Res. 1979;49:213-23 PMID: 42113
  19. Independent activation of the acetylcholine receptor from Torpedo californica at two sites.
    Biochemistry. 1980 Mar 4;19(5):890-5 PMID: 7356966
  20. On the mechanism of desensitization at cholinergic receptors.
    Mol Pharmacol. 1970 Jul;6(4):357-82 PMID: 5429280
  21. Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by Torpedo postsynaptic membranes: stoichiometry and ligand interactions.
    Biochemistry. 1979 Nov 27;18(24):5464-75 PMID: 518850
  22. Molecular mechanism of acetylcholine receptor-controlled ion translocation across cell membranes.
    Proc Natl Acad Sci U S A. 1980 Feb;77(2):842-6 PMID: 6928684
  23. Kinetics of agonist conductance changes during hyperolarization at frog endplates.
    Br J Pharmacol. 1975 Feb;53(2):308-10 PMID: 1080064
  24. Regulation of binding properties of the nicotinic receptor protein by cholinergic ligands in membrane fragments from Torpedo marmorata.
    Proc Natl Acad Sci U S A. 1975 Sep;72(9):3443-7 PMID: 1059130
  25. Functional consequences of agonist-mediated state transitions in the cholinergic receptor. Studies in cultured muscle cells.
    J Biol Chem. 1979 May 10;254(9):3315-25 PMID: 429353
  26. Correlation of polypeptide composition with functional events in acetylcholine receptor-enriched membranes from Torpedo californica.
    Proc Natl Acad Sci U S A. 1979 Dec;76(12):6265-9 PMID: 293719
  27. Voltage-dependent and voltage-independent blockade of acetylcholine receptors by local anesthetics in Electrophorus electroplaques.
    Mol Pharmacol. 1979 May;15(3):559-80 PMID: 492146
  28. Single-channel currents recorded from membrane of denervated frog muscle fibres.
    Nature. 1976 Apr 29;260(5554):799-802 PMID: 1083489
  29. A comparison of current-voltage relations for full and partial agonists.
    J Physiol. 1978 Oct;283:621-44 PMID: 309943
  30. Quinacrine (mepacrine) action at frog end-plate.
    J Physiol. 1980 Sep;306:261-81 PMID: 6257896
  31. Role of voltage-sensitive receptors in nicotinic transmission.
    Biophys J. 1978 Mar;21(3):181-94 PMID: 630039
  32. A re-examination of curare action at the motor endplate.
    Proc R Soc Lond B Biol Sci. 1978 Dec 4;203(1151):119-33 PMID: 33387
  33. Drug blockade of open end-plate channels.
    J Physiol. 1976 Sep;260(3):531-52 PMID: 10432
  34. An analysis of the dose-response relationship at voltage-clamped frog neuromuscular junctions.
    J Physiol. 1978 Aug;281:421-44 PMID: 309004
  35. Response of acetylcholine receptors to photoisomerizations of bound agonist molecules.
    Biophys J. 1978 Oct;24(1):135-60 PMID: 708818
  36. Voltage-dependence of drug-induced conductance in frog neuromuscular junction.
    Proc Natl Acad Sci U S A. 1975 Jun;72(6):2140-4 PMID: 1079601
  37. Synaptic membrane structure in Torpedo electric organ.
    J Neurocytol. 1975 Dec;4(6):697-712 PMID: 1194931
  38. A study of the desensitization produced by acetylcholine at the motor end-plate.
    J Physiol. 1957 Aug 29;138(1):63-80 PMID: 13463799
  39. Binding of antibodies to acetylcholine receptors in Electrophorus and Torpedo electroplax membranes.
    J Cell Biol. 1978 Mar;76(3):577-92 PMID: 344325
  40. Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides.
    Proc Natl Acad Sci U S A. 1979 Feb;76(2):690-4 PMID: 34154
  41. A quantitative analysis of local anaesthetic alteration of miniature end-plate currents and end-plate current fluctuations.
    J Physiol. 1977 Jan;264(1):89-124 PMID: 190384
  42. Identification of a local anesthetic binding site in nicotinic post-synaptic membranes isolated from Torpedo marmorata electric tissue.
    Mol Pharmacol. 1979 Mar;15(2):294-312 PMID: 470931
  43. Analysis of atropine action at the frog neutromuscular junction.
    J Physiol. 1977 Jul;269(1):109-30 PMID: 302330
  44. Determination of dose-response curves by quantitative ionophoresis at the frog neuromuscular junction.
    J Physiol. 1978 Aug;281:395-419 PMID: 309003
  45. Relaxation experiments using bath-applied suberyldicholine.
    J Physiol. 1977 Jun;268(2):271-89 PMID: 301569
  46. Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. III. Pharmocological desensitization in vitro of the receptor-rich membrane fragments by cholinergic agonists.
    J Mol Biol. 1976 Sep 25;106(3):485-96 PMID: 978732
  47. The effect of procaine on neuromuscular transmission.
    J Physiol. 1970 Aug;209(3):689-99 PMID: 5499803
  48. The effect of voltage on the time course of end-plate currents.
    J Physiol. 1972 May;223(1):151-71 PMID: 4537943
  49. The effect of calcium on the desensitization of membrane receptors at the neuromuscular junction.
    J Gen Physiol. 1966 May;49(5):963-76 PMID: 5961360
  50. Interaction of a fluorescent probe with acetylcholine-activated synaptic membrane.
    Nature. 1977 Oct 13;269(5629):609-11 PMID: 917107
  51. Local anaesthetics transiently block currents through single acetylcholine-receptor channels.
    J Physiol. 1978 Apr;277:153-76 PMID: 306437
  52. An analysis of the dose-response curve at voltage-clamped frog-endplates.
    Pflugers Arch. 1975 Oct 28;360(2):145-53 PMID: 1237869
  53. Difference in effects of end-plate potentials between procaine and lidocaine as revealed by voltage-clamp experiments.
    J Neurophysiol. 1971 Jan;34(1):32-46 PMID: 4322252
  54. Mode of action of quinacrine on the acetylcholine receptor ionic channel complex.
    Mol Pharmacol. 1979 Sep;16(2):382-92 PMID: 316101
  55. Ligand specificity of state transitions in the cholinergic receptor: behavior of agonists and antagonists.
    Mol Pharmacol. 1979 Mar;15(2):197-212 PMID: 470928
  56. End-plate channel opening and the kinetics of quinacrine (mepacrine) block.
    J Physiol. 1980 Sep;306:283-306 PMID: 6257897
  57. Fast kinetic studies on the interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata.
    Eur J Biochem. 1979 Feb 15;94(1):255-79 PMID: 436843
  58. Effect of histrionicotoxin on the ionic conductance modulator of the cholinergic receptor: a quantitative analysis of the end-plate current.
    J Pharmacol Exp Ther. 1974 May;189(2):513-24 PMID: 4545376
  59. An analysis of the action of atropine and scopolamine on the end-plate current of frog sartorius muscle.
    J Pharmacol Exp Ther. 1976 Feb;196(2):360-72 PMID: 1082932
  60. The extracellular patch clamp: a method for resolving currents through individual open channels in biological membranes.
    Pflugers Arch. 1978 Jul 18;375(2):219-28 PMID: 567789
  61. Voltage- and time-dependent action of histrionicotoxin on the endplate current of the frog muscle.
    J Gen Physiol. 1978 Sep;72(3):351-67 PMID: 308995
  62. Acetylcholine receptor and ionic channel of Torpedo electroplax: binding of perhydrohistrionicotoxin to membrane and solubilized preparations.
    Biochemistry. 1978 Dec 12;17(25):5474-84 PMID: 728410
  63. The permeability of the endplate channel to organic cations in frog muscle.
    J Gen Physiol. 1980 May;75(5):469-92 PMID: 6247422
  64. Noise and relaxation studies of acetylcholine induced currents in the presence of procaine.
    J Physiol. 1978 May;278:237-50 PMID: 671293
  65. A study of desensitization using voltage clamp.
    Pflugers Arch. 1975 Oct 28;360(2):135-44 PMID: 1081218
  66. A quantitative description of membrane current and its application to conduction and excitation in nerve.
    J Physiol. 1952 Aug;117(4):500-44 PMID: 12991237
  67. Desensitisation does not selectively alter sodium channels.
    Nature. 1977 Aug 11;268(5620):553-5 PMID: 301991
  68. Kinetic analysis of end plate currents altered by atropine and scopolamine.
    Mol Pharmacol. 1978 May;14(3):514-29 PMID: 307112
  69. Desensitization and recovery at the frog neuromuscular junction.
    J Gen Physiol. 1977 Apr;69(4):431-47 PMID: 300785
  70. Fast cation flux from Torpedo californica membrane preparations: implications for a functional role for acetylcholine receptor dimers.
    Biochem Biophys Res Commun. 1978 Nov 29;85(2):632-40 PMID: 736923
  71. Kinetics of agonist-mediated transitions in state of the cholinergic receptor.
    J Biol Chem. 1977 Nov 10;252(21):7648-56 PMID: 914831
  72. Ion-concentration dependence of the reversal potential and the single channel conductance of ion channels at the frog neuromuscular junction.
    J Physiol. 1979 Jan;286:417-45 PMID: 312319
  73. Voltage dependence of agonist responses at voltage-clamped frog endplates.
    Pflugers Arch. 1976 Jan 30;361(2):145-51 PMID: 943088
  74. Reconstitution of carbamylcholine-dependent sodium ion flux and desensitization of the acetylcholine receptor from Torpedo californica.
    J Biol Chem. 1978 Oct 10;253(19):6660-2 PMID: 690117
  75. Binding of perhydrohistrionicotoxin to intact and detergent-solubilized membranes enriched in nicotinic acetylcholine receptor.
    Biochemistry. 1979 May 15;18(10):1868-74 PMID: 435450
  76. Interaction of permeant ions with channels activated by acetylcholine in Aplysia neurones.
    J Physiol. 1979 Dec;297(0):9-45 PMID: 536927
  77. Desensitization onset and recovery at the potassium-depolarized frog neuromuscular junction are voltage sensitive.
    J Gen Physiol. 1978 Mar;71(3):285-99 PMID: 650169
  78. Agonist-mediated changes of the acetylcholine receptor in its membrane environment.
    J Mol Biol. 1978 Sep 5;124(1):1-26 PMID: 712829
  79. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons.
    J Gen Physiol. 1971 Oct;58(4):413-37 PMID: 5112659
  80. Modes of action of gallamine at the neuromuscular junction [proceedings].
    Br J Pharmacol. 1979 May;66(1):78P-79P PMID: 454963
  81. Voltage- and time-dependent actions of piperocaine on the ion channel of the acetylcholine receptor.
    Mol Pharmacol. 1979 Nov;16(3):909-21 PMID: 316855
  82. Affinity directed crosslinking of acetylcholine receptor polypeptide components in post-synaptic membranes.
    Biochem Biophys Res Commun. 1978 Nov 29;85(2):623-31 PMID: 736922
  83. Frequency of opening of channels by depolarizing drugs [proceedings].
    J Physiol. 1978 Nov;284:149P-150P PMID: 731495
  84. The actions of tubocurarine at the frog neuromuscular junction.
    J Physiol. 1979 Aug;293:247-84 PMID: 315462
  85. Kinetics of agonist-induced intrinsic fluorescence changes in membrane-bound acetylcholine receptor.
    Nature. 1976 Sep 30;263(5576):429-31 PMID: 972683
  86. The mode of action of antagonists of the excitatory response to acetylcholine in Aplysia neurones.
    J Physiol. 1978 May;278:207-35 PMID: 671288
  87. Fast kinetic studies on the allosteric interactions between acetylcholine receptor and local anesthetic binding sites.
    Eur J Biochem. 1979 Feb 15;94(1):281-96 PMID: 436844
  88. Postsynaptic membranes in the electric tissue of Narcine: II. A freeze-fracture study of nicotinic receptor molecules.
    Tissue Cell. 1977;9(4):595-608 PMID: 610002
  89. Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica.
    J Mol Biol. 1979 Mar 5;128(3):319-34 PMID: 439138
  90. Mechanism of action of amantadine on neuromuscular transmission.
    Mol Pharmacol. 1978 Sep;14(5):787-803 PMID: 213703
  91. Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica.
    J Mol Biol. 1977 Nov;116(4):635-59 PMID: 563472
  92. Carbamylcholine-induced rapid cation efflux from reconstituted membrane vesicles containing purified acetylcholine receptor.
    Biochem Biophys Res Commun. 1979 Jul 12;89(1):26-35 PMID: 475810
  93. Ionic blockage of sodium channels in nerve.
    J Gen Physiol. 1973 Jun;61(6):687-708 PMID: 4541078
  94. Dependence of acetylcholine desensitization on the membrane potential of frog muscle fibre and on the ionic changes in the medium.
    J Physiol. 1970 Oct;210(3):507-18 PMID: 5499808
  95. Numerical reconstruction of the quantal event at nicotinic synapses.
    Biophys J. 1979 Jul;27(1):145-64 PMID: 262376
  96. Fluctuation and relaxation analysis of monazomycin-induced conductance in black lipid membranes.
    J Membr Biol. 1976 Jun 30;27(4):347-62 PMID: 966263
  97. Decamethonium both opens and blocks endplate channels.
    Proc Natl Acad Sci U S A. 1978 Jun;75(6):2994-8 PMID: 307251
  98. Acetylcholine receptor: covalent attachment of depolarizing groups at the active site.
    Science. 1969 Jun 20;164(3886):1420-1 PMID: 5783718
  99. Movement of labelled decamethonium in muscle fibres of the rat.
    J Physiol. 1977 Nov;272(2):283-94 PMID: 592193
  100. A morphological study of the cholinergic receptor protein from Torpedo marmorata in its membrane environment and in its detergent-extracted purified form.
    J Cell Sci. 1978 Feb;29:313-37 PMID: 627610
  101. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.
    J Gen Physiol. 1973 Jul;62(1):37-57 PMID: 4541340
  102. Relaxation and fluctuations of membrane currents that flow through drug-operated channels.
    Proc R Soc Lond B Biol Sci. 1977 Nov 14;199(1135):231-62 PMID: 22856
  103. Alteration by xylocaine (lidocaine) and its derivatives of the time course of the end plate potential.
    J Gen Physiol. 1968 Jul;52(1):144-61 PMID: 4316945
  104. Rates and equilibria at the acetylcholine receptor of Electrophorus electroplaques: a study of neurally evoked postsynaptic currents and of voltage-jump relaxations.
    J Gen Physiol. 1977 Aug;70(2):187-219 PMID: 894257
  105. Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques.
    J Gen Physiol. 1975 Jun;65(6):797-816 PMID: 1194885
  106. Ligand-induced conformation changes in Torpedo californica membrane-bound acetylcholine receptor.
    Biochemistry. 1978 Jun 13;17(12):2405-14 PMID: 678518
  107. Voltage dependence of agonist effectiveness at the frog neuromuscular junction: resolution of a paradox.
    J Physiol. 1975 Oct;251(2):245-70 PMID: 1081139
  108. Organization of acetylcholine receptors in quick-frozen, deep-etched, and rotary-replicated Torpedo postsynaptic membrane.
    J Cell Biol. 1979 Jul;82(1):150-73 PMID: 479296
  109. Influence of SKF-525A congeners, strophanthidin and tissue-culture media on desensitization in frog skeletal muscle.
    Br J Pharmacol. 1974 Jun;51(2):259-68 PMID: 4155972
  110. A model for the procaine end-plate current.
    J Physiol. 1975 Mar;246(2):61P-63P PMID: 1142273
  111. Response of acetylcholine receptors to rapid photochemically produced increases in agonist concentration.
    Nature. 1977 Mar 24;266(5600):373-4 PMID: 859605
  112. Single ionic channels observed in tissue-cultured muscle.
    Nature. 1979 Dec 20-27;282(5741):861-3 PMID: 514365
  113. Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle.
    Biophys J. 1977 Dec;20(3):343-68 PMID: 21711
  114. An analysis by low-angle neutron scattering of the structure of the acetylcholine receptor from Torpedo californica in detergent solution.
    Biophys J. 1979 Dec;28(3):473-96 PMID: 262562
Article Info
Journal
The Journal of membrane biology
Abbr.
J Membr Biol
ISSN
0022-2631
DOI
10.1007/BF01870902
Published
1981-02-28
Pages
161-74
Language
English
Region
United States
NLM ID
0211301
Subset
IM
Grants
NINDS NIH HHS · NS-14920 · United States
External Links
PubMed source DOI: 10.1007/BF01870902 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2