Home LiteratureArticle Details
PMID: 2579095 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Host genetic regulation of acute MHV-4 viral encephalomyelitis and acute experimental autoimmune encephalomyelitis in (BALB/cKe x SJL/J) recombinant-inbred mice.

Journal of neuroimmunology ·Vol. 8 ·No. 1 ·1985-04-00 ·Pages 15-28

Knobler RL, Linthicum DS, Cohn M

Abstract

In the present report we provide the strain distribution patterns of susceptibility to acute mouse hepatitis virus type-4 (MHV-4) encephalomyelitis, acute experimental allergic encephalomyelitis (EAE) and vasoactive amine sensitivity (VAAS) for 9 (CXJ) recombinant-inbred strains between BALB/cKe (C) and SJL/J(J) mice. We confirm that susceptibility to MHV-4 is not linked to the H-2 complex, and that all strains susceptible to acute EAE have both a responder H-2 haplotype (H-2s or H-2d) and induced (B. pertussis) VAAS. In addition, we provide evidence that susceptibility to acute EAE induction is controlled by an additional presently unmapped locus and that an EAE-like histopathological disease does not usually follow MHV-4 infection intracerebrally in animals susceptible to MHV-4, acute EAE and induced VAAS.

MeSH Terms
Animals Bordetella pertussis/immunology Drug Hypersensitivity/etiology Encephalomyelitis/genetics,immunology Encephalomyelitis, Autoimmune, Experimental/genetics,immunology Female H-2 Antigens/immunology Haploidy Hepatitis, Viral, Animal/genetics,immunology Histamine/immunology Humans Immunity, Innate Male Mice Mice, Inbred Strains Murine hepatitis virus Myelin Basic Protein/immunology Rats
Chemicals
H-2 Antigens Myelin Basic Protein Histamine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Knobler R L
Linthicum D S
Cohn M
References (28)
28 references, click to expand
  1. Genetic study of mouse sensitivity to MHV3 infection: influence of the H-2 complex.
    J Immunol. 1979 Apr;122(4):1359-62 PMID: 448093
  2. Host genetic control of mouse hepatitis virus type-4 (JHM strain) replication. II. The gene locus for susceptibility is linked to the Svp-2 locus on mouse chromosome 7.
    Exp Clin Immunogenet. 1984;1(4):217-22 PMID: 6101098
  3. Genetic determinants of virus susceptibility: epidemiologic implications of murine models.
    Epidemiol Rev. 1981;3:115-39 PMID: 6273199
  4. Chronic measles encephalitis in mice.
    J Infect Dis. 1980 Oct;142(4):608-13 PMID: 7441020
  5. Pathogenesis of murine cytomegalovirus infection: the macrophage as a permissive cell for cytomegalovirus infection, replication and latency.
    J Gen Virol. 1979 Aug;44(2):349-59 PMID: 230287
  6. Neuropathology of experimental allergic encephalomyelitis in inbred strains of mice.
    Lab Invest. 1980 Aug;43(2):150-7 PMID: 7401630
  7. Histocompatibility-linked immune response genes.
    Science. 1972 Jan 21;175(4019):273-9 PMID: 4109878
  8. Delayed, relapsing experimental allergic encephalomyelitis in mice.
    J Immunol. 1981 Mar;126(3):819-22 PMID: 7462632
  9. Experimental allergic encephalomyelitis in inbred and outbred mice.
    J Immunol. 1973 Jan;110(1):139-43 PMID: 4631068
  10. Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes.
    Transplantation. 1971 Mar;11(3):325-7 PMID: 5558564
  11. Congenic strains of mice susceptible and resistant to mouse hepatitis virus.
    Proc Soc Exp Biol Med. 1976 Sep;152(4):499-502 PMID: 135262
  12. Susceptibility of inbred mice to chronic central nervous system infection by Theiler's murine encephalomyelitis virus.
    Infect Immun. 1979 Oct;26(1):369-74 PMID: 500211
  13. Pathogenesis of demyelination induced by a mouse hepatitis.
    Arch Neurol. 1973 May;28(5):298-303 PMID: 4348723
  14. Action of the histamine sensitizing factor from Bordetella pertussis on inbred and random bred strains of mice.
    Int Arch Allergy Appl Immunol. 1968;34(4):331-8 PMID: 4176640
  15. Measles encephalomyelitis--clinical and immunologic studies.
    N Engl J Med. 1984 Jan 19;310(3):137-41 PMID: 6197651
  16. Infectious leukoencephalitis. A critical comparison of certain experimental and naturally-occurring viral leukoencephalitides with experimental allergic encephalomyelitis.
    J Neuropathol Exp Neurol. 1962 Oct;21:491-518 PMID: 13998401
  17. The EAE Model: A Tentative Connection to Multiple Sclerosis.
    Science. 1977 Mar 11;195(4282):969-71 PMID: 17735664
  18. Acute autoimmune encephalomyelitis in mice. II. Susceptibility is controlled by the combination of H-2 and histamine sensitization genes.
    J Exp Med. 1982 Jul 1;156(1):31-40 PMID: 6806429
  19. Selected mutants of mouse hepatitis virus type 4 (JHM strain) induce different CNS diseases. Pathobiology of disease induced by wild type and mutants ts8 and ts15 in BALB/c and SJL/J mice.
    Am J Pathol. 1982 Nov;109(2):157-68 PMID: 6291396
  20. Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis.
    Nature. 1983 Sep 8-14;305(5930):150-3 PMID: 6310411
  21. Virus persistence and recurring demyelination produced by a temperature-sensitive mutant of MHV-4.
    Nature. 1982 Jul 15;298(5871):279-80 PMID: 6283382
  22. A MURINE VIRUS (JHM) CAUSING DISSEMINATED ENCEPHALOMYELITIS WITH EXTENSIVE DESTRUCTION OF MYELIN : II. PATHOLOGY.
    J Exp Med. 1949 Aug 31;90(3):195-212 PMID: 19871701
  23. Regulation of immunity toward allogeneic tumors in mice. I. Effect of antiserum fractions on tumor growth.
    J Natl Cancer Inst. 1969 Oct;43(4):843-56 PMID: 5344181
  24. Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination.
    Proc Natl Acad Sci U S A. 1978 Aug;75(8):4033-6 PMID: 279022
  25. Mouse hepatitis virus type 4 (JHM strains). induced fatal central nervous system disease. I. genetic control and murine neuron as the susceptible site of disease.
    J Exp Med. 1981 Apr 1;153(4):832-43 PMID: 6265583
  26. Genetic analysis of susceptibility to isoniazid-induced seizures in mice.
    Genetics. 1976 Jun;83(2):373-7 PMID: 17248721
  27. Myelin basic protein: structure, function and antigenic determinants.
    Immunol Rev. 1978;39:60-107 PMID: 75170
  28. Mechanism of demyelination in JHM virus encephalomyelitis. Electron microscopic studies.
    Acta Neuropathol. 1973 Mar 30;24(1):76-85 PMID: 4349379
Article Info
Journal
Journal of neuroimmunology
Abbr.
J Neuroimmunol
ISSN
0165-5728
DOI
10.1016/s0165-5728(85)80044-8
Published
1985-04-00
Pages
15-28
Language
English
Region
Netherlands
NLM ID
8109498
PMCID
PMC7119749
Subset
IM
Grants
NIAID NIH HHS · AI 1 P40 RR01 641-01 · United States
NINDS NIH HHS · NS-12428 · United States
NINDS NIH HHS · NS08003 · United States
External Links
PubMed source DOI: 10.1016/s0165-5728(85)80044-8 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2