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PMID: 6806429 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Acute autoimmune encephalomyelitis in mice. II. Susceptibility is controlled by the combination of H-2 and histamine sensitization genes.

The Journal of experimental medicine ·Vol. 156 ·No. 1 ·1982-07-01 ·Pages 31-40

Linthicum DS, Frelinger JA

Abstract

The expression of acute experimental autoimmune encephalomyelitis (EAE) in mice is controlled by several dominant genes, H-2 and histamine sensitization genes. SJL/J and SWR/J, which are H-2s and H-2q, respectively, are susceptible to EAE and sensitive to Bordetella pertussis histamine-sensitizing factor (HSF), which produces a vasoactive amine hypersensitivity. Other H-2s or H-2q strains such as A.SW, B10.Q and several others do not develop acute EAE and are not sensitive to B. pertussis HSF. One strain tested, DDD (KsIsD?) is HSF sensitive but does not develop EAE (presumably because it lacks the appropriate responder H-2 haplotype). However, F1 hybrids between B10.S and DDD are sensitive to HSF and develop EAE. The induction and effector phases of acute EAE are apparently controlled by the combination of H-2 and HSF genes. A combination of the correct H-2 hapotype and histamine sensitivity is required for the development of acute EAE.

MeSH Terms
Acute Disease Adjuvants, Immunologic/pharmacology Animals Encephalomyelitis, Autoimmune, Experimental/genetics,immunology Female Genes, MHC Class II H-2 Antigens/genetics,immunology Histamine/genetics,immunology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Mice, Inbred DBA Mice, Inbred NZB Pertussis Toxin Recombination, Genetic Virulence Factors, Bordetella
Chemicals
Adjuvants, Immunologic H-2 Antigens Virulence Factors, Bordetella Histamine Pertussis Toxin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Linthicum D S
Frelinger J A
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.156.1.31
Published
1982-07-01
Pages
31-40
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186733
Subset
IM
Grants
NCI NIH HHS · CA-22662 · United States
External Links
PubMed source DOI: 10.1084/jem.156.1.31 PMC Full Text View journal details
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