A simplified method for calculating complex metabolic sensitivities by using matrix partitioning.

The Biochemical journal ·Vol. 263 ·No. 1 ·1989-10-01 ·Pages 289-92

Crabtree B, Collins G, Franklin MI

Abstract

The matrix method for calculating the overall sensitivities (including control coefficients) of a metabolic system, described by Crabtree & Newsholme [Biochem. J. 247, 113-129 (1987)], is simplified by a preliminary partitioning of the initial matrix equation. This reduces the size of the matrix to be inverted and thereby removes a major drawback with the original method. The resulting procedure is simpler and more systematic than the alternative methods currently available, especially when the system is extensively branched.

MeSH Terms

Mathematics Metabolism

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Crabtree B

Rowett Research Institute, Aberdeen, Scotland, U.K.

Collins G

Franklin M I

References (11)

11 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj2630289

Published

1989-10-01

Pages

289-92

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1133422

Subset

External Links

PubMed source DOI: 10.1042/bj2630289 PMC Full Text View journal details

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A simplified method for calculating complex metabolic sensitivities by using matrix partitioning.

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