Microbial glycosylation of erythromycin A.

Antimicrobial agents and chemotherapy ·Vol. 33 ·No. 12 ·1989-12-00 ·Pages 2089-91

Kuo MS, Chirby DG, Argoudelis AD, Cialdella JI, Coats JH, Marshall VP

Abstract

Erythromycin A (compound 1) was inactivated by Streptomyces vendargensis ATCC 25507 in fermentation. The inactivation product was isolated and characterized by nuclear magnetic resonance and mass spectroscopy as 2'-(O-[beta-D-glucopyranosyl])erythromycin A (compound 2). The MICs of compounds 1 and 2 were determined. Compound 2 lacked antibiotic activity when tested against several gram-positive pathogens, as well as S. vendargensis.

MeSH Terms

Chromatography, Thin Layer Erythromycin/metabolism,pharmacology Fermentation Glycosylation Gram-Positive Bacteria/drug effects Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Streptomyces/drug effects,metabolism

Chemicals

Erythromycin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Kuo M S

Chemical and Biological Screening, Upjohn Company, Kalamazoo, Michigan 49001.

Chirby D G

Argoudelis A D

Cialdella J I

Coats J H

Marshall V P

References (12)

12 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.33.12.2089

Published

1989-12-00

Pages

2089-91

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC172826

Subset

External Links

PubMed source DOI: 10.1128/AAC.33.12.2089 PMC Full Text View journal details

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